Nghiên cứu hiệu quả và an toàn của chất làm đầy acid hyaluronic và calcium hydroxyapatite trong trẻ hóa bàn tay

Abstract

Objective: To compare the efficacy and safety of two dermal fillers, calcium hydroxylapatite (CaHA) and hyaluronic acid (HA), in hand rejuvenation. Subject and method: A randomized single-blind clinical trial was conducted in 22 women aged 27-64 years presented at Ho Chi Minh City Hospital of Dermato-Venereology with grade 2 or higher hand aging according to the Merz Hand Grading Scale (MHGS). Participants were randomly injected with HA (Restylane Lyft) in one hand and CaHA (Radiesse) in the other hand. Assessment was done immediately after injection, at 2, 4, and 12 weeks, including pain, adverse effects, aesthetic improvement using the Global Aesthetic Improvement Scale (GAIS), and satisfaction. A blinded dermatologist evaluated aesthetic improvement using MHGS and GAIS. Result: Both fillers significantly improved hand aging according to MHGS, with an average reduction of 1.6-2.3 grades. GAIS improvement was moderate to excellent according to expert and patient evaluation. All patients were satisfied to very satisfied with treatment results at all assessment points. Patients aged ≤ 45 years or with MHGS grade ≤ 2 were more satisfied with CaHA injection, while those aged > 45 years or with MHGS grade > 2 were more satisfied with HA injection. Adverse effects, including pain, swelling, and redness, were significantly higher in the CaHA-injected hand (54-63%) than in the HA-injected hand (14-27%). These adverse effects were mild and self-limiting within 2-3 days. No serious adverse effects were observed. Conclusion: Both HA and CaHA fillers are effective in hand rejuvenation with mild and self-limiting adverse effects. CaHA injection is associated with a higher frequency of adverse effects than HA injection.