Nghiên cứu hiệu quả của phương pháp tách đáy sẹo kết hợp laser CO2 vi điểm đồng thì so với khác thì trong điều trị sẹo rỗ do mụn trứng cá

Abstract

Objective: To compare the effectiveness of simultaneous versus sequential fractional CO₂ laser and subcision combination for post-acne atrophic. Subject and method: This is a single-blind, split-face clinical trial including 16 patients with post-acne atrophic scars in Ho Chi Minh City Hospital of Dermatology and Venereology. Each patient underwent three sessions of subcision combined with fractional CO₂ laser with a 1-month interval between sessions. The face’s left side is treated with simultaneous combination therapy, while the face’s right side receives sequential combination therapy. The efficacy of the treatment was assessed at week 4, 8 and 12. Result: No significant differences were found in patient-assessed treatment efficacy (p=1.000, 1.000, 0.329). Comparable results were observed when evaluated by a blinded dermatologist (p=1.000, 1.000, and 0.976). Time was a main significant factor affecting acne scar severity (p<0.001). There was no significant interaction between the time factor and treatment method (p=0.647). The main effect of treatment method was not significant (p=0.835). Regarding adverse events, the simultaneous treatment group experienced longer swelling time (p<0.001), shorter downtime (p<0.001), and higher pain level during laser treatment (p=0.022). Conclusion: Despite the longer swelling time and higher pain levels during laser treatment in the simultaneous group, the effectiveness and satisfaction level of CO₂ fractional laser and subcision for acne scars was equivalent between the two combinations, with shorter downtime for the simultaneous combination compared to the sequential combination.