ISSN: 1859 - 2872
The efficacy of intralesional injection of 5-fluorouracil plus hyaluronidase in the treatment of acne keloid
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Abstract
Objective: To assess the effects of intralesional injection 5-fluorouracil and hyaluronidase in the treatment of acne keloid. Subject and method: Thirty patients aged 18 years and older with acne keloid were enrolled from August 2016 to August 2017 at Hospital of Dermato-Venereology, Ho Chi Minh City. Patients with full criteria were applied with EMLA® 5% cream in 30 minutes, injecting intralesional 5-fluorouracil and hyaluronidase, a dose of 0.2ml/cm2 scars acreage, once a week. The treatment outcome was evaluated at week 4, 8, 12, 16 and after one and three months of treatment basing on the criteria of Henderson and El-Tonsy. The clinical improvement was evaluated by Shivaswamy KN. The complete blood count was performed before treatment and once a month during treatment to follow side effects. This study was approved by Research Ethics Committee of Hospital of Dermato-Venereology. Data were analyzed by STATA ver. 20.0 software. Result: 86.7% of the patients were males, the age group from 20 to 30 years old was 83.3%, 43.3% of the patients were students. Keloids with less than 2 years were: 46.7%, itching: 66.7%, erythema: 60%, keloids on the chest: 46.7%, keloids < 5cm2: 73.3%. The mean times of intralesional injection were 10.9 ± 2.1. Of these patients, 63.3% had good response. None of the 30 patient in our study had blood test disorder. Mild pain was seen in 100% of patients. No case of keloids was associated with relapse after three and six months treament period. Conclusion: A combination of 5-fluorouracil and hyaluronidase is new, effective, and safe modality, less recurrence in the treament of acne keloid.
Keywords: Acne, keloids, 5-fluorouracil.
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References
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