ISSN: 1859 - 2872
Evaluation of the efficacy of treating dermatophytic onychomycosis with the combination of fractional CO2 laser and topical clotrimazole
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Abstract
Summary
Objective: To evaluate the efficacy of treating dermatophytic onychomycosis with the combination of fractional CO2 laser and topical clotrimazole. Subject and method: We performed this study on 45 patients ≥ 18 years old with dermatophytic onychomycosis in Thu Duc Hospital from September 2018 to June 2019. The onychomycosis cases were diagnosed by clinical features, direct microscopic examination of the wet mount preparation. The severity of the cases was assessed by SCIO (Scoring clinical index for onychomycosis). All patients were treated by Lutronic® Fractional CO2 Laser twice a week for 6 consecutive weeks plus topical clotrimazole 1% continuingly in 3 months. Efficacy was assessed after treatment by SCIO, patients’ satisfaction and wet mount examination. The protocol was approved by the Scientific Council of Thu Duc Hospital and data was analyzed by SPSS 20.0 software. Result: Women consisted of 57.8%, the age group 25 - 60 made up of 62.2%, the mean duration of onychomycosis was 1.2 ± 1.6 years and 77.8% of the patients had the condition for the first time. Mean SCIO before treatment was 7.5 ± 7.1 and 73.3% of the patients were negative with wet mount examination. Mean SCIO dropped to 2.4 ± 5.8 after treatment with statistical significance and 82.2% of the patients were very satisfied or satisfied. All of the patients reported transient mild pain. Conclusion: The combination of fractional CO2 laser with topical clotrimazole 1% was highly effective and safe in the treatment of dermatophytic onychomycosis.
Keywords: Dermatophytosis, dermatophytes, fraction CO2 laser.
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References
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