ISSN: 1859 - 2872
Role of plasma vitamin D and iron in the prognosis of mortality in patients with sepsis
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Abstract
Objective: To determine 30-day mortality prognostic value of plasma vitamin D and iron levels in patients with sepsis. Subject and method: A prospective descriptive study was conducted on 125 patients with sepsis treated at 108 Military Central Hospital from November 2019 to February 2021. Plasma vitamin D and iron levels were measured at the time of definitive diagnosis with sepsis, 30-day follow-up of survival and mortality. Result: The plasma vitamin D and iron levels at the time of definitive diagnosis with sepsis were 20.41 (15.03-30.25) ng/mL and 1.9 (1.0-4.0) µmol/L, respectively. The levels of plasma vitamin D in the 30-day mortality group were lower than the survival group (p=0.004). Patients with plasma vitamin D levels < 15.74ng/mL had a higher risk of 30-day mortality than patients with plasma vitamin D levels ≥ 15.74ng/mL, OR 4.26 (1.84-9.90), p<0.001. The plasma iron levels in the 30-day mortality group were higher in the survival group (p=0.016). Patients with plasma iron levels ≥ 1.75µmol/L had a higher risk of 30-day mortality than patients with iron levels < 1.75µmol/L, OR = 3.63 (1.49-8.86), p=0.003. Conclusion: Plasma vitamin D levels < 15.74ng/mL and plasma iron levels ≥ 1.75µmol/L may be risk factors for 30-day mortality in patients with sepsis.
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References
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