ISSN: 1859 - 2872
Association between plasma zinc concentration and outcomes of patients with sepsis
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Abstract
Objective: To describe plasma zinc (Zn) concentration and assess the association between plasma Zn concentration and outcomes of patients with sepsis. Subject and method: A prospective descriptive study was conducted on 125 patients with sepsis treated at 108 Military Central Hospital from November 2019 to February 2021. Plasma Zn concentrations were measured at admission (Zn1) and at day 3 after admission (Zn3), 30-day follow-up of survival and mortality. Result: The rate of Zn1 deficiency was 48.8%. The plasma Zn1 and Zn3 concentrations were 54.0 (37.15-74.4) vs 68.7 (55.3-89.2) µg/dL respectively, p<0.001. The group with SOFA score < 7 points had higher Zn1 concentration than the group with SOFA score ≥ 7 points, p<0.01. There was no statistically significant difference in plasma Zn1 concentrations between the shock group and the non-shock group, between the mechanical ventilation group and non-ventilation group, between the renal group and non-renal failure group, between the liver failure group and non-liver failure group, between the 30-day mortality group and survival group. Conclusion: Zn1 deficiency was common in patients with sepsis. Plasma Zn1 concentration was lower than plasma Zn3 concentration. The group with a higher SOFA score had a lower concentration of Zn1, p<0.01. The 30-day mortality and survival groups had no difference in Zn1 concentrations.
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References
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