ISSN: 1859 - 2872
Current status of HDV infection at 108 Military Central Hospital
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Abstract
Objective: To assess the prevalence of hepatitis Delta virus and genotypes distributions in 108 Military Central Hospital. Subject and method: A total of 546 HBV-infected patients were enrolled from 2013 to 2015 at the 108 Military Central Hospital, and classified clinically into the subgroups of chronic hepatitis B (CHB, n = 191), liver cirrhosis (LC, n = 147) and hepatocellular carcinoma (HCC, n = 208). The patients were screened for HDV-RNA by nested PCR assays. HDV genotypes were assessed by direct sequencing, followed by phylogenetic analyses. Result: HDV-RNA was identified in 13% (71/546) of HBV-infected patients. The highest HDV prevalence was found in the LC group (19.7%), followed by the HCC (12%) and CHB (8.9%) groups (p=0.012). Phylogenetic analyses indicated that the genotype HDV1 was, with a prevalence of 91%, by far the most common genotype in Vietnam, followed by HDV2 with 9%. Other HDV genotypes were not observed. Conclusion: High prevalence of HDV infection in hepatitis B patients in 108 Military Central Hospital, with the HDV1 genotype still being the predominant genotype. HDV nucleic acid testing to minimize the associated risk should be considered.
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References
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