Đánh giá kết quả cắt lớp vi tính mô phỏng sử dụng đồng thời thuốc cản quang đường tĩnh mạch và đường uống trong xác định thể tích khối u thô xạ trị ung thư thực quản

Abstract

Objective: To evaluate the results of computed tomography simulation technique using intravenous and oral contrast agents simultaneously in determining the gross tumor volume (Gross Tumor Volume - GTV), radiotherapy planning esophageal cancer. Subject and method: A descriptive retrospective study on 315 esophageal cancer patients with indications for radiation therapy, who underwent computed tomography simulation using intravenous and oral contrast agents at the Oncology Center of 103 Military Hospital from March 2015 to December 2022. Result: The technique was applicable to all esophageal cancer sites. Compared with CT simulation without contrast, this technique changed GTV in 85.40% of patients; detected more lesions, enlarged gross tumor volume in 21.59% of patients; remove healthy tissue from the GTV in 45.40% of patients. The percentage of patients with changes in both directions including detecting additional lesions and removing healthy tissue from the gross tumor volume was 18.41%. There were 14.60% of patients with similar gross tumor volume on both techniques. Conclusion: Simulated computed tomography technique using intravenous and oral contrast agents simultaneously in radiation therapy for esophageal cancer helps to determine the gross tumor volume more accurately than simulated CT without contrast, helping to avoid missing lesions, and at the same time minimizing harm to healthy tissues. This technique should be used routinely in radiation therapy for esophageal cancer.