ISSN: 1859 - 2872
Evaluation of 4DCT-based dose distribution simulation in non-small cell lung cancer radiotherapy at 175 Military Hospital
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Abstract
Objective: To evaluate the dose distribution of 4DCT-based dose simulation compared to 3DCT-based simulation. Subject and method: The gross tumor volume (GTV) and clinical target volume (CTV) were delineated in all 10 respiratory phases of 30 non-small cell lung cancer (NSCLC) patients who underwent 4DCT imaging. The PTV-3D was created from CT1 dataset and the PTV-4D from AVG10 dataset. The planned treatment volume (PTV) and volume dose histogram (DVH) were compared between 3D and 4D treatment plans. Result: The mean volumes of PTV3D and PTV4D were 460 ± 179 (69-820) cm3 and 401 ± 167 (127-854) cm3, respectively with p=0.0018. The 4DCT-based radiotherapy dose distribution was lower than that of 3DCT. Compared to 3DCT, the V5, V10, and V20 values for lung were 55.8%, 40.5%, and 28.9% for 4DCT and 59.9%, 44.6%, and 31.2% for 3DCT respectively, with significant differences. However, there was no significant difference in the dose distribution of V30 for lung, heart, esophagus, and spinal cord. Conclusion: The conformity index (CI) and dose homogeneity index (DHI) were not significantly different between the two techniques. The normal tissue complication probability (NTCP) of lung and heart in the 4DCT plan.
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References
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