ISSN: 1859 - 2872
Early results of definitive concurrent chemoradiation therapy using intensity modulated radiotherapy technique in upper-third esophageal cancer patients at Hanoi Oncology Hospital
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Abstract
Objective: This study aims to evaluate treatment response and acute side effects of definitive concurrent chemoradiation therapy with intensity-modulated radiotherapy (IMRT) technique in upper-third esophageal cancer patients. Subject and method: An interventional study on 31 upper-thirds esophageal cancer patients treated by definitive concurrent chemoradiation therapy using IMRT technique with cisplatin/5FU regimen at Hanoi Oncology Hospital in 2022. Treatment response and acute side effects were assessed by RECIST 1.1 and CTCAE 5.0, respectively. Result: 83.9% of patients had dysphagia improvement. Treatment response rates were: Complete response 19.4%, partial response 61.2%, stable disease 9.7%, and progressive disease 9.7%. There were significant differences in response rates among disease stage and radiation dose (p<0.05). The most side effects were grade 1-2, including dermatitis (61.3%), esophagitis (96.8%), vomiting (62%), amenia (35.5%), and neutropenia (19.4%); 4 patients (12.8%) were suffered from grade 3-4. Conclusion: Definitive concurrent chemoradiation with IMRT technique in upperthird esophageal cancer patients was safe and efficacy.
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References
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