Effects of dioxin exposure on the physical development of 5-year-old children in Bien Hoa, Vietnam

  • Thiều Ban Trang Học viện Quân y
  • Phạm Thế Tài Học viện Quân y
  • Muneko Nishijo Đại học Y khoa Kanazawa, Nhật Bản
  • Phạm Ngọc Thảo Bệnh viện Quân đội 103
  • Nguyễn Xuân Kiên Học viện Quân y
  • Kingkeo SengKhamYong Học viện Quân y Lào
  • Trần Ngọc Anh Học viện Quân y

Main Article Content

Keywords

Children, body sizes, dioxin exposure, physical development

Abstract

Objective: To investigate the effects of perinatal dioxin exposure on the physical development of 5 years old children. Subject and method: 185 pairs of mother-infant living in Bien Hoa (dioxin-contaminated area) and 104 pairs of mother-infant living in Ha Dong (control area) were collected. Dioxin exposure of infants was estimated by the measurement of dioxin concentrations in breast milk of nursing mothers. The height, weight, head circumference and BMI were measured and the associations between these indicators and the levels of dioxin exposure were assessed. Result: The concentrations of dioxin in breast milk of mothers in Bien Hoa were 2-3 times higher than those of mothers in Ha Dong. In both boys and girls, almost of body indicators of Bien Hoa group were significantly higher than those of Ha Dong group. Positive relationships were found between body indexes and dioxin exposure levels. Conclusion: Perinatal exposure to dioxin can affect physical development of 5-year-old children.

Article Details

References

1. Tai PT, Nishijo M, Kido T, Nakagawa H, Maruzeni S, Naganuma R, Anh NT, Morikawa Y, Luong HV, Anh TH, Hung NN, Son le K, Tawara K, Nishijo H (2011) Dioxin concentrations in breast milk of Vietnamese nursing mothers: a survey four decades after the herbicide spraying. Environmental Science & Technology 45: 6625-6632.
2. Guo YL, Lambert GH, Hsu CC, Hsu MM (2004) Yucheng: Health effects of prenatal exposure to polychlorinated biphenyls and dibenzofurans. Int Arch Occup Environ Health 77(3): 153-158.
3. Iszatt N, Stigum H, Govarts E, Murinova LP, Schoeters G, Trnovec T, Legler J, Thomsen C, Koppen G, Eggesbø M (2016) Perinatal exposure to dioxins and dioxin-like compounds and infant growth and body mass index at seven years: A pooled analysis of three European birth cohorts. Environ 94: 399-407.
4. Eskenazi B, Mocarelli P, Warner M, Chee WY, Gerthoux PM, Samuels S, Needham LL, Patterson DG Jr (2003) Maternal serum dioxin levels and birth outcomes in women of Seveso, Italy. Environmental health perspectives 111(7): 947-953.
5. Tai PT, Nishijo M, Nghi TN, Nakagawa H, Van Luong H, Anh TH, Nishijo H (2016) Effects of perinatal Dioxin exposure on development of children during the first 3 years of life. J Pediatr 175: 159-166.
6. Wang Z, Hang JG, Feng H, Shi LL, Dong JJ, Shen B, Luo T, Cai RM, Shen LJ, Kido T, Sun XL (2019) Effects of perinatal dioxin exposure on development of children: A 3-year follow-up study of China cohort. Environ Sci Pollut Res Int 26(20): 20780-20786.
7. Nhu DD, Kido T, Hung NN, Thom LTH, Naganuma R, Son LK, Honma S, Maruzeni S, Nishijo M, Nakagawa H (2011) Dioxin levels in the breast milk and estradiol and androgen levels in the saliva of Vietnamese primiparae. Toxicological & Environmental Chemistry 93: 824-838.
8. Su PH, Chen JY, Chen JW, Wang SL (2010) Growth and thyroid function in children with in utero exposure to Dioxin: A 5-year follow-up study. Pediatric Research 67(2): 205-210.
9. Tzoulaki I, Sovio U, Pillas D, Hartikainen AL, Pouta A, Laitinen J, Tammelin TH, Jarvelin MR, Elliott P (2010) Relation of immediate postnatal growth with obesity and related metabolic risk factors in adulthood: the northern Finland birth cohort 1966 study. Am J Epidemiol 171(9): 989-98.
10. Rennert A, Wittsiepe J, Kasper-Sonnenberg M, Binder G, Fürst P, Cramer C, Krämer U, Wilhelm M (2012) Prenatal and early life exposure to polychlorinated dibenzo-p-dioxins, dibenzofurans and biphenyls may influence dehydroepiandrosterone sulfate levels at prepubertal age: Results from the Duisburg birth cohort study. J Toxicol Environ Health A 75(19-20): 1232-1240.