Relationship between BMD and fat mass, lean mass, serum leptin, adiponectin in people over 40 years old with metabolic syndrome

  • Ngô Thị Thu Thủy Bệnh viện Đại học Y Hải Phòng
  • Phạm Văn Thức Đại học Y Dược Hải Phòng
  • Nguyễn Ngọc Châu Bệnh viện Trung ương Quân đội 108

Main Article Content

Keywords

leptin, adiponectin, Lean mass, fat mass, bone density

Abstract

Objective: To investigate the relationship between BMD and fat mass, muscle mass, serum leptin, adiponectin, and components of metabolic syndrome in people over 40 years of age. Subject and method: Analytical cross-sectional study on 128 people with metabolic syndrome. BMD, fat mass, lean mass measured by DXA. Diagnosis hypertension according to the recommendations of the Vietnam Heart Association (ACC/AHA 2017), diagnosis of diabetes according to the recommendations of the ADA 2017, diagnosis of metabolic syndrome according to the NCEP/ATP III updated 2005. Result: The BMD of people with metabolic syndrome was positively correlated with total body fat mass, FMI index, and body mass (p<0.05), inversely related with fat ratio A/G (p<0.05). There was no relationship between serum leptin concentration (p>0.05) and bone density but there was an inverse relationship between adiponectin concentration and bone density (p<0.05). Among the components of the metabolic syndrome, only waist circumference was negatively related with rib density. Conclusion: Total fat mass and lean lean mass mass were positively related to BMD of ribs, BMD of spines, total BMD but A/G fat ratio were negatively related to BMD of pelvis, total BMD, waist circumference were negatively related to BMD of  ribs, and adiponectin concentrations were negatively related with BMD of ribs BMD of pelvis, serum leptin level were not related to BMD in people with metabolic syndrome.

Article Details

References

1. Wong SK, Chin KY, Suhaimi FH, Ahmad F, Ima-Nirwana S (2016) The Relationship between metabolic syndrome and osteoporosis: A review. Nutrients 8(6):347. doi: 10.3390/nu8060347.
2. Hilton C, Vasan SK, Neville MJ, Christodoulides C, Karpe F (2022) The associations between body fat distribution and bone mineral density in the Oxford Biobank: A cross sectional study. Expert Rev Endocrinol Metab 17(1): 75-81.
3. Zillikens MC, Uitterlinden AG, van Leeuwen JP, Berends AL, Henneman P, van Dijk KW, Oostra BA, van Duijn CM, Pols HA, Rivadeneira F (2010) The role of body mass index, insulin, and adiponectin in the relation between fat distribution and bone mineral density. Calcif Tissue Int 86(2): 116-125.
4. Iacobellis G, Iorio M, Napoli N, Cotesta D, Zinnamosca L, Marinelli C, Petramala L, Minisola S, D'Erasmo E, Letizia C (2011) Relation of adiponectin, visfatin and bone mineral density in patients with metabolic syndrome. J Endocrinol Invest 34(1): 12-15.
5. Chin KY, Chan CY, Subramaniam S, Muhammad N, Fairus A, Ng PY, Jamil NA, Aziz NA, Ima-Nirwana S, Mohamed N (2020) Positive association between metabolic syndrome and bone mineral density among Malaysians. Int J Med Sci 17(16): 2585-2593.
6. Lê Minh Thùy, Tăng Kim Hồng, Lê Minh Trung (2021) Mối liên quan giữa hội chứng chuyển hóa và loãng xương ở phụ nữ trên 50 tuổi. Tạp chí Nghiên cứu Y Học 143(7): 108-114.
7. Pomeroy E, Macintosh A, Wells JCK, Cole TJ, Stock JT (2018) Relationship between body mass, lean mass, fat mass, and limb bone cross-sectional geometry: Implications for estimating body mass and physique from the skeleton. Am J Phys Anthropol 166(1): 56-69.
8. Mathieu M, Guillot P, Riaudel T, Boureau AS, Chapelet G, Brouessard C, de Decker L, Berrut G (2021) Association between bone mineral density and fat mass independent of lean mass and physical activity in women aged 75 or older. Nutrients 13(6): 1994. doi: 10.3390/nu13061994.
9. Ansari MGA, Hussain SD, Wani KA, Yakout SM, Al-Disi D, Alokail MS, Reginster JY, Al-Daghri NM (2020) Influence of bone mineral density in circulating adipokines among postmenopausal Arab women. Saudi J Biol Sci 27(1): 374-379.
10. Shu L, Fu Y, and Sun H (2022) The association between common serum adipokines levels and postmenopausal osteoporosis: A meta-analysis. J Cell Mol Med 26(15): 4333-4342.