ISSN: 1859 - 2872
The association between plasma homocysteine level and 24 hour ambulatory blood pressure and arterial stiffness in primary hypertensive patients
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Abstract
Objective: We investigated the association between serum homocysteine and ambulatory arterial stiffness index and some characteristics of 24 hour ambulatory blood pressure in primary hypertensive patients. Subject and method: 87 primary hypertensive patients were enrolled. The association between serum homocysteine and 24h blood pressure characteristics and AASI was analysed. Result: 81.6% of the patients had high serum homocysteine, the mean serum homocysteine level was 43.00 ± 21.22µmol/l. There were mild positive correlations between homocysteine level and average daytime systolic blood pressure (SBP), average daytime diastolic blood pressure (DBP), average nighttime SBP, average nighttime DBP, average 24h SBP and average 24h DBP, p<0.05. Homocysteine level in patients with increased AASI were higher than in those with normal AASI, p<0.001. There was a fair correlation between serum homocysteine and AASI (r = 0.565; p<0.001). Conclusion: Plasma homocysteine level was associated with 24 hour blood pressure and arterial stiffness in patients with primary hypertension.
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References
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