ISSN: 1859 - 2872
Left ventricular function assessed with two-dimensional speckle tracking and three-dimensional echocardiography in patients with obstructive sleep apnea
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Abstract
Objective: To investigate left ventricular function by two-dimensional (2D) speckle tracking and three-dimensional (3D) echocardiography in obstructive sleep apnea (OSA) patients. Subject and method: Patients who were diagnosed with OSA based on the results of full polysomnography and had apnea- hypopnea index values > 5 events/hour of sleep were included in the study. All patient underwent polysomnography recording. Comprehensive 2-dimensional echocardiography were performed to all subjects according to American Society of Echocardiography guidelines [5], followed by real-time 3D echocardiography. Result: From June 2021 to June 2022, there were 46 OSA patients were included in the study. Mean age of OSA patients 51.3 ± 11.7 years. Men 63% (29/46), women 37% (15/46). The apnea-hypopnea index, percentage of total sleep time with an oxygen saturation level < 90%, arousal index increased in OSA patients. E/E’ increased (12.6 ± 4.3), GLS mildly reduced (-16.5 ± 3.8%) while other echocardiographic parameters were in normal range. Results of ANOVA showed an increase in the following LA parameters on 3D echocardiography according to the levels of OSA severity: LV mass index, 3D maximum LA volume, 3D maximum LA volume index, E/E’ were significantly higher in the severe OSA group compared with the moderate OSA and the mild OSA (p<0.05 for all). There was a decrease in the E’ velocity and global longitudinal strain (GLS) (p<0.05 for all). Conclusion: In patients with obstructive sleep apnea, the severity of OSA was associated with lower E′ velocity, greater E/E′ ratio, larger 3D LV volume, greater LV mass index, and poorer left ventricular global longitudinal strain.
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2. Young T, Finn L, Peppard PE, Szklo-Coxe M, Austin D, Nieto FJ, Stubbs R, Hla KM (2008) Sleep disordered breathing and mortality: Eighteen-year follow-up of the Wisconsin sleep cohort. Sleep 31: 1071-1078.
3. Herrscher T, Akre H, Overland B et al (2011) High prevalence of sleep apnea in heart failure outpatients: Even in patients with preserved systolic function. J Card Fail 17(5): 420-425.
4. Berry R (2011) Fundamentals of sleep medicine. Elsevier Health Sciences. 1st Edition.
5. Lang RM, Badano LP, Mor-Avi V et al (2015) Recommendations for cardiac chamber quantification by echocardiography in adults: An update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging. Eur Heart J Cardiovasc Imag 16: 233-270.
6. Ogivile R, Genuardi M, Redline S et al (2020) Association between sleep disordered breathing and left ventricular function. A cross-sectional analysis of the ECHO-SOL Ancillary Study. Circulation: Cardiovascular Imaging 13:009074. DOI: 10.1161/CIRCIMAGING.119.009074.
7. Kim SM, Cho KI, Kwon JH, Lee HG, Kim TI (2012) Impact of obstructive sleep apnea on left atrial functional and structural remodeling beyond obesity. J Cardiol 60: 475-483.
8. Koka AR, Gould SD, Owen AN, Halpern EJ (2012) Left atrial volume: comparison of 2D and 3D transthoracic echocardiography with ECG-gated CT angiography. Acad Radiol 19(1): 62-68.
9. Otto ME, Belohlavek M, Romero-Corral A, Somers VK et al (2007) Comparison of cardiac structural and functional changes in obese otherwise healthy adults with versus without obstructive sleep apnea. Am J Cardiol 99: 1298-1302.
10. Fredgart MH, Carter-Storch R, Møller JE, Diederichsen ACP et al (2018) Measurement of left atrial volume by 2D and 3D non-contrast computed tomography compared with cardiac magnetic resonance imaging. Int J Cardiovasc Imaging 34(3): 337-342. doi: 10.1007/s10554-017-1243-7.
11. Usui Y, Takata Y, Inoue Y, Shimada K, Tomiyama H, Nishihata Y, Kato K, Shiina K, Yamashina A (2012) Coexistence of obstructive sleep apnoea and metabolic syndrome is independently associated with left ventricular hypertrophy and diastolic dysfunction. Sleep Breath 16: 677-684.
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