ISSN: 1859 - 2872
Study of microsatellite instability in colorectal adenocarcinoma by immunohistochemistry
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Abstract
Objective: To identify features of microsatellite instability in colorectal adenocarcinoma. Subject and method: A retrospective, descriptive, cross - sectional study was performed on 79 patients with colorectal adenocarcinoma treated by immunohistochemistry at the 103 Military Central Hospital from January 2020 to April 2022. Result: 26.58% of colorectal adenocarcinoma patients suffered microsatellite instability, of which the majority lost the expression with immunohistochemical markers of MLH1-PMS2 (61.19%) and MSH2MSH6 (23.81%). Only 2 patients lost expression with MSH6 marker, and 1 patient lost expression with PMS2 marker. A statistically correlation (p<0.05) was found between microsatellite instability and different groups of patients with studied characteristics relating location, size, histopathological subtypes, or histological grade. Conclusion: The status of microsatellite instability is essential in the classification and treatment of colorectal cancer patients, especially under the common adenocarcinoma group.
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References
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