ISSN: 1859 - 2872
Successful treatment of drug-resistant Pustular Psoriasis with Secukinumab monotherapy: A case report
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Abstract
Generalized pustular psoriasis (GPP) is a rare disease and has a high rate of resistance with traditional systemic management such as methotrexate and cyclosporine. Acitretin is considered as first–line treatment for GPP, however, it is contraindicated for patients with dyslipidemia, increased liver enzymes or women in reproductive age. Morever, acitretin is only effective in pustule clearance and has a modest effect with psoriasis lesion, besides, it also has numerous adverse effects. Many biological therapies approved to be used to treat plaque psoriasis are also approved to be used as a therapy for GPP. In this article, we present a case of a patient with generalized pustular psoriasis after having COVID–19 vaccination and treated successfully with secukinumab monotherapy, after the failure of cyclosporine A and acitretin.
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References
2. Ho PH, Tsai TF (2003) Successful treatment of refractory juvenile generalized pustular psoriasis with secukinumab monotherapy: A case report and review of published work. Arch Dermatol Res 295: 43-54. [PubMed] [Google Scholar].
3. Polesie S, Lidholm AG (2017) Secukinumab in the treatment of generalized pustular psoriasis: A case report. Acta Derm Venereol 97(1): 124-125.
4. Robinson A, Van Voorhees AS, Hsu S, Korman NJ, Lebwohl MG, Bebo BF, et al (2012) Treatment of pustular psoriasis: from the medical board of the national psoriasis foundation. J Am Acad Dermatol Venereol 67: 279-288. [PubMed] [Google Scholar].
5. Imafuku S, Homma M, Okubo Y, Komine M, Ohtsuki M, Morita A et al (2016) Efficacy and safety of seckukinumab in patients with generalized pustular psoriasis: A 52 week analysis from phase III open-label multicentre Japanese study. J Dermatol 43: 1011-1017. [PubMed] [Google Scholar].
6. Yeung J, Valbuena V (2016) Successful use of seckukinumab in pustular psoriasis. J Am Acad Case Rep 2: 470-472. [Google Scholar].
7. Polesie S, Lidholm AG (2017) Seckukinumab in the treatment of generalized pustuar psoriasis: A case report. Acta Derm Venereol 96: 124-125 [PubMed] [Google Scholar].
8. Böhner A, Roenneberg S, Eyerich K, Eberlein B, Biedermann T (2016) Acute generalized pustular psoriasis treated with IL-17 A antibody seckukinumab. JAMA Dermatol 152: 482-484. [PubMed] [Google Scholar].
9. Umezawa Y, Ozawa A, Kawasima T, Shimizu H, Terui T, Taqami H, et al (2003) Therapeutic guidelines for the treatment of generalized pustular psoriasis (GPP) based on a proposed classification of disease severity. Arch Dermatol Res 295: 43-54. [PubMed] [Google Scholar].
10. Madanagobalane S (2018) Secukinumab in generalized pustular psoriasis. Indian Dermatol Online J 9(6): 464-466. doi: 10.4103/idoj.IDOJ_93_18, PMCID: PMC6233 001PMID: 30505796.
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