ISSN: 1859 - 2872
Efficacy of autologous intrauterine infusion of platelet-rich plasma in recurrent implantation failure patients
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Abstract
Objective: To evaluate pregnancy rates in patients with a history of two consecutive recurrent implantation failure (RIF) among patients who received autologous platelet-rich plasma (PRP) infusions before embryo transfer and those who did not. Subject and method: A retrospective cohort study of 414 RIF patients at the Fertility Center of Tam Anh General Hospital between 2020 and 2022. Result: There were no statistically significant differences between the groups for age, body mass index, infertility causes, previous cesarean delivery, or previous laparoscopic surgery for infertility (55 patients in the PRP group and 359 patients in the control group). Pregnancy rates in both groups were comparable (49.0% in the PRP group and 49.6% in the control group; p=0.97). Rates of biochemical pregnancy (7% vs. 7.8%, p=0.93), clinical pregnancy (42% vs. 41.8%, p=0.94), miscarriage (7% vs. 6.7%, p=0.85), ongoing pregnancy (35% vs. 35%, p=0.99), or embryo implantation (42% vs. 30%, p=0.21) did not differ significantly. However, the PRP group had a higher implantation rate (41.5% vs 30%, p=0.001) and a higher rate of ongoing pregnancy (34.1% vs 31.2%, p=0.79) among patients with a history of three or more consecutive failed embryo transfers. Conclusion: The pregnancy rate after embryo transfer did not differ significantly between the RIF patients with endometrial thickness higher than 9mm who underwent PRP infusion and the control group. Since the PRP group had a greater implantation rate than the control group, it should be considered in RIF patients with three or more consecutive failed embryo transfers.
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References
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