Đặc điểm hình ảnh của bệnh lý Castleman gan: Báo cáo trường hợp bệnh và tổng hợp y văn

Abstract

Hepatic Castleman disease (HCD) is very rare disease characterized by lymph node hyperplasia and that is easy to mimics with other hepatic mass. We report a 24 year-old male with chronic hepatitis B visited Vietnam National Cancer Hospital with right upper quadrant discomfort. Ultrasound and computer tomography showed a giant right hepatic tumor. Hepatocellular carcinomar (HCC) was suspected. Biomarkers for liver cancer (aFP, CEA, CA 19-9) was normal. After ultrasound-guided liver biopsy, histopathology revealed Castleman’s disease. We report a case of HCD and review its pathological and imaging characteristics of 18 cases in 17 papers of hepatic Castleman's disease published in the US National Library (Pubmed) and the ScienceDirect database of Elsevier publishers. The results of the literature review showed the hepatic Castleman disease characteristics: With 19 patients (14 women and 5 men), out case and 18 patients in database review, women and men ratio was 2.8, with mean age of 48.3 ± 16.2 years (range, 24-70 years). The most common age of hyaline - vascular type was 20-40 years old (85.7%). There was correlation between the age and histopathological type (p=0.017). Most patients who came to the hospital was no symptom. Radiological features: The most common of mass was well - define in the hilum (89.5%). On abdominal ultrasound, hypoechoic mass was in 80% of all case and 61.5% of hyaline vascular type, there was correclation between the echoic mass and histopathological type (p=0.049). On CT, mass showed hypodense on non – enhancement phase (61.3%), hypervascular in the arterial phase (88.2%), isodense on portal venous phase (46.7%). There was no correlation between the CT features and histopathological type (p=0.314).