Osmotic demyelination syndrome, overcorrection of severe hyponatremia: A case report

  • Lưu Thúy Quỳnh Bệnh viện Trung ương Quân đội 108
  • Phạm Văn Cường Bệnh viện Trung ương Quân đội 108
  • Nguyễn Thị Thủy Bệnh viện Trung ương Quân đội 108
  • Vũ Thị Loan Bệnh viện Trung ương Quân đội 108
  • Nguyễn Thị Thùy Linh Bệnh viện Trung ương Quân đội 108
  • Lê Bích Nhàn Bệnh viện Trung ương Quân đội 108
  • Nguyễn Văn Mạnh Bệnh viện Trung ương Quân đội 108
  • Phạm Hồng Nhung Bệnh viện Trung ương Quân đội 108
  • Lê Thu Hiền Bệnh viện Trung ương Quân đội 108
  • Ngô Thị Phượng Bệnh viện Trung ương Quân đội 108

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Keywords

Osmotic demyelination syndrome, hyponatremia

Abstract

The osmotic demyelination syndrome (ODS) has been recognized as a complication of the rapid correction of hyponatremia. The pathophysiology of ODS consists loss of myelin due to osmotic stress. It has a high mortality and usually need aggressive supportive management in the intensive care unit. We report a case of ODS due to overcorrection of severe hyponatremia with pathognomonic clinical and radiologic signs making a nearly complete neurological recovery. Conclusion: Osmoic demyelination syndrome is a complication of overcorrection of severe hyponatremia. Treatment options for ODS are limited to case report however a combination of immunoglobulin, steroid and plasma exchange was administered not only during the early stage of illness but also helped to improve the neurological outcome.

Article Details

References

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Published
Dec 1, 2022
DOI: https://doi.org/10.52389/ydls.v17i7.1557
Issue
Volume 17-No 7/2022
Section
Articles
How to Cite
Thúy QuỳnhL., Văn CườngP., Thị ThủyN., Thị LoanV., Thị Thùy LinhN., Bích NhànL., Văn MạnhN., Hồng NhungP., Thu HiềnL., & Thị PhượngN. (2022). Osmotic demyelination syndrome, overcorrection of severe hyponatremia: A case report. Tạp Chí Y Dược lâm sàng 108, 17(7). https://doi.org/10.52389/ydls.v17i7.1557