Mối tương quan giữa nồng độ beta-2 microglobulin và một số chỉ số dẫn truyền thần kinh ở bệnh nhân suy thận mạn giai đoạn cuối

Abstract

Objective: To determine the mean concentration of β2-M, disturbance of nerve conduction studies and the correlation between the concentration of β2-M and nerve conduction studies in end stage renal disease (ESRD) patients on hemodialysis. Subject and method: A cross-sectional descriptive study in 80 ESRD patients on hemodialysis at Can Tho General hospital from July 2021 to July 2022. Result: The mean concentration of β2-M was 24.8 ± 3.38mg/l. In peroneal nerve, decrease in compound muscle action potential amplitude (CMAP) was 75%, decrease in motor conduction velocity (MCV) was 70%, prolongation of distal latency (dL) was 51.2%. There was 61.2% of patients decrease MCV in tibal nerve. In sensory ulnar nerve, prolongation of dL was 72.5%, decrease of sensory conduction velocity (SCV) was 71.3%. In the sensory median nerve, decrease SCV and prolongation of dL were 75% and 70%, respectively. There was a moderate correlation between β2-M concentration and distal latency of peroneal nerve (r = 0.44, p=0.001), tibia nerve (r = 0.43, p=0.001), inverse correlation with the tibial nerve MCV (r = -0.32, p=0.004). Conclusion: Serum β2-M level were high and correlated with nerve conduction studies in patients with ESRD on hemodialysis.