Research of ventricular arrhythmias on Holter ECG and relationship with late potentials in coronary artery disease patients

  • Nguyễn Dũng 108 Military Central Hospital
  • Phạm Nguyên Sơn 108 Military Central Hospital
  • Phạm Thái Giang 108 Military Central Hospital

Main Article Content

Keywords

Late potential, signal-averaged ECG, Holter ECG, coronary artery disease

Abstract

Objective: To study ventricular arrhythmias and the relationship with late potentials in patients with coronary artery disease (CAD). Subject and method: A descriptive, cross-sectional study. Using signal-averaged electrocardiogram on 162 patients with coronary artery disease treated at 108 Military Central Hospital from September 2016 to October 2018. Result: The frequency of ventricular ectopic was 94.4%, of which severe ventricular arrhythmias (Lown 3-5) accounted for 34.0%. The rate of abnormal late potential was 38.3%. There was a relationship between late potential and complex ventricular arrhythmias (OR = 23.82, p<0.05). If the late potential was abnormal, the risk of complicated ventricular arrhythmia was more likely (72.6%), whereas if the late voltage was normal, there was only 10.0% risk of complicated ventricular arrhythmia. Conclusion: Late potential was associated with ventricular arrhythmias, sensitivity of 81.8% and specificity of 84.1%. In abnormal late potential group: 72.6% had ventricular arrhythmias, while in normal late potential group severe ventricular arrhythmias was rare (10%). Normal late potentials results rule out the risk of dangerous arrhythmias without further intervention.

Article Details

References

1. Lê Ngọc Hà (2003) Nghiên cứu rối loạn nhịp tim và mối liên quan với tái cấu trúc thất trái ở bệnh nhân sau nhồi máu cơ tim. Học viện Quân y, Học viện Quân y.
2. Huỳnh Văn Minh (2014) Holter điện tâm đồ 24 giờ trong bệnh lý tim mạch. Nhà xuất bản Đại học Huế, tr. 166.
3. Nguyễn Lân Việt (2014) Thực hành bệnh tim mạch: Bệnh tim thiếu máu cục bộ mạn tính. Nhà xuất bản y học, Hà Nội.
4. Piwowarska W, Sniezek-Maciejewska M, Trusz-Gluza M, Piwoński M, Giec L, Dabrowski A, Kubik L, Mamcarz A, Swiatowiec A, Kopeć P et al (1990) Complex ventricular arrhythmias in ischemic heart disease. Kardiol Pol 33(3): 151-157.
5. Lown B, Wolf M (1971) Approaches to sudden death from coronary heart disease. Circulation 44: 130-142.
6. Lee JB, Lee YS, Hong SP, Kim SY, Kim MG, Ryu JK, Choi JY, Kim KS, Chang SG (2008) Prognostic significance of the lown grades and late potentials in patients after myocardial infarction. Korean Circ J 38(1): 17-22. https://doi.org/10.4070/kcj.2008.38.1.17.
7. Denes P, Santarelli P, Masson M, Uretz EF (1987) Prevalence of late potentials in patients undergoing Holter monitoring. American heart journal 113(1): 33-36. doi: 10.1016/0002-8703(87)90006-8.
8. Soyza ND, Murphy ML, Bissett JK, Kane JJ (1977) Detecting ventricular arrhythmia after myocardial infarction: comparison of Hoiter monitoring and treadmill exercise. Southern medical journal 70(4): 403-404.
9. Zimmermann M, Adamec R, Simonin P, Richez J (1985) Prognostic significance of ventricular late potentials in coronary artery disease. American Heart Journal 109(4): 725-732.
10. Gatzoulis KA, Arsenos P, Trachanas K, Dilaveris P, Antoniou C, Tsiachris D, Sideris S, Kolettis TM, Tousoulis D (2018) Signal-averaged electrocardiography: Past, present, and future. J Arrhythm 34(3): 222-229.
11. Srinivasan NT and Schilling RJ (2018) Sudden cardiac death and arrhythmias. Arrhythm Electrophysiol Rev 7(2): 111-117.