ISSN: 1859 - 2872
Evaluation of weight, transverse diameter and volume changes after 20 fractions of intensity-modulated radiotherapy for patient with nasopharygeal carcinoma
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Abstract
Objective: To evaluate changes of the weight, transverse diameter and volume after 20 fractions of intensity-modulated radiotherapy (IMRT) for patients with nasopharygeal carcinoma (NPC). Subject and method: A retrospective study of 63 stage II-IVB NPC patients received IMRT concurrently with triweekly cisplatin from September 2016 to March 2020 at 108 Military Central Hospital. Patients received a new computed tomography simulation after 20 fractions. Result: The weight, transverse diameter of the nasopharyngeal, the neck, GTV-tumor, GTV-lymph node, CTV and 2 parotid glands volume were decreased significantly at time after 20th fraction compared with before treatment (mean reduction 3.79 ± 2.29kg, 0.77 ± 0.48cm, 0.79 ± 0.63cm, 6.25 ± 7.82cm3, 12.37 ± 16.37cm3, 38.93 ± 31.83cm3, 5.65 ± 4.57cm3, 6.14 ± 4.92cm3, respectively; p=0.0001). The transverse diameter of the nasopharyngeal, the neck reduction were significantly correlated with 2 parotid glands volume reduction (r = 0.76, p=0.0001, r = 0.69, p=0.0001, r = 0.66, p=0.0001 và r = 0.65, p=0.0001, respectively). However, no significant correlation was observed between weight loss and GTV, CTV, 2 parotid glands volume reduction. Conclusion: The significant reduction in transverse diameter of the nasopharyngeal, the neck, GTV-tumor, GTV-lymph node, CTV and 2 parotid glands volume suggests the need for replanning after 20 fractions during IMRT with NPC
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References
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