Ảnh hưởng của một số yếu tố lên độ nặng và diễn tiến của bệnh ở bệnh nhân mắc COVID-19 điều trị nội trú tại Bệnh viện Quân dân Y miền Đông

Abstract

Objective: To evaluate the effects of the COVID-19 vaccines, ages, gender, BMI, co-morbidity on the severity and progression of illness in COVID-19 inpatients treated at the Eastern Military Hospital from July 2021 to November 2021. Subject and method: Descriptive study on 244 patients hospitalized for treatment at Covid 1 Department of Mien Dong Military Hospital, disease progression (no conversion, conversion but improved treatment, conversion required intensive care). were recorded, and the associations between vaccination, age, sex, BMI, comorbidities and disease severity, time of negative PCR, length of hospital stay, and disease outcome were investigated. Result: The level of patients with mild, moderate and severe - critical in 3 groups included 17.5%, 38.1%, 44.4% in unvaccinated patients, 44.4%, 67.0%, 26.6% in one-dose vaccinated patients, 7.3%, 81.7%, 17.0% two-dose vaccinated and 1.3% (p<0.001). The time of PCR for negative resuls of the 3 groups above were 18.2% ± 3.8, 13.6 ± 2.9 and 12.7 ± 1.9 days, respectively (p<0.001). The duration of inpatient treatment of the 3 groups were 18.65 ± 4.71, 16.13 ± 2.61 and 15.10 ± 1.68 days, respectively (p<0.001). The rate of severe disease requiring intensive care treatment of 3 groups were 20.6%, 5.1% and 0.0%, respectively (p<0.001). Other factors affecting the disease progression of COVID-19 were surveyed including overweight and obesity (p<0.001), hypertension (p=0.003), heart failure (p=0.048), COPD (p=0.038), asthma (p=0.012), tuberculosis (p=0.004), number of underlying diseases ≥ 3 (p=0.001), smoking (p<0.001). Conclusion: Factors such as vaccine, age, sex, BMI, comorbidities, have an effect on the severity of COVID-19 disease, shortening the time of negative PCR and hospital stay, and significantly reducing the conversion rate require active resuscitation.