Monocyte distribution width (MDW) in patients with sepsis admitted to the Emergency Department of Bach Mai Hospital
Main Article Content
Keywords
Abstract
Objective: To evaluate the characteristics of monocyte distribution width (MDW) in patients with sepsis emergency admitted to Bach Mai Hospital. Subject and method: A prospective, cross-sectional study of patients (≥ 18 years of age) admitted to the A9 Emergency Center from April to May 2022 who were the complete blood count and MDW. A total of 606 patients were recruited in the study and were divided into 2 groups: 144 patients with sepsis according to Sepsis-3 criteria and 462 patients in the control group without sepsis. Result: The MDW value in patients with sepsis (31.16 ± 8.22) was significantly higher than that in the group without sepsis (18.92 ± 2.86) (p<0.001). MDW in the group of multiorgan failure was 34.74 ± 9.49 significantly higher than that in organ dysfunction group < 2 organs was 28.67 ± 6.12 (p<0.001). MDW in patients with septic shock (38.74 ± 8.95) was significantly higher than that in the group without septic shock (28.34 ± 5.83) (p<0.001). MDW in non-survival group (38.94 ± 10.04) was significantly higher than in survival group (29.60 ± 6.86) (p<0.001). Conclusions: MDW value was significantly higher in the sepsis group than that in the control group. MDW increased with the severity of sepsis (MDW in the survival group, multi-organ failure group and septic shock group was significantly higher than the survival group, < 2 organ failure and no septic shock group).
Article Details
References
2. Crouser ED, Parrillo JE, Martin GS et al (2020) Monocyte Distribution Width Enhances Early Sepsis Detection in the Emergency Department Beyond SIRS and qSOFA, Journal Intensive Care 8: http 33.doi: 10.1186/s40560-020-00446.
3. Crouser ED, Parrillo JE, Seymour CW et al (2019) Monocyte distribution width: A novel indicator of sepsis-2 and sepsis-3 in high-risk emergency department patients. Crit Care Med 47(8): 1018-1025.
4. Crouser ED et al (2017) Improved early detection of sepsis in the ED with a novel monocyte distribution width biomarker. 152 (3): 518-526.
5. David J Sturgess, Thomas H Marwick et al (2010) Prediction of hospital outcome in septic shock: A prospective comparison of tissue Doppler and cardiac biomarkers. Crit Care 14(2): 44.
6. Woo A, Oh DK, Park CJ, Hong SB (2021) Monocyte distribution width compared with C-reactive protein and procalcitonin for early sepsis detection in the emergency department. PLoS One 16(4): 0250101. doi:10.1371/journal.pone.0250101.
7. Luisa Agnello et al (2020) Monocyte distribution width (MDW) as a screening tool for sepsis in the Emergency Department. Clin Chem Lab Med 58(11): 1951-1957.
8. Mardi D, Fwity B, Lobmann R, Ambrosch (2010) A Mean cell volume of neutrophils and monocytes compared with C-reactive protein, interleukin-6 and white blood cell count for prediction of sepsis and nonsystemic bacterial infections. Int J Lab Hematol 32: 410-418.
9. Rudd, et al(2020) Global, regional, and national sepsis incidence and mortality, 1990-2017: Analysis for the Global Burden of Disease Study. Lancet Jan 18: 200-211.
10. Juehui Wu, Laisheng Li et al (2022) Diagnostic and prognostic value of monocyte distribution width in sepsis. J Inflamm Res 15: 4107-4117.