Evaluation of the effectiveness of chronic urticaria treatment with 10mg oral dose of levocetirizine
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Abstract
Objective: Evaluation of the effectiveness of chronic urticaria treatment with a 10mg oral dose of levocetirizine. Subject and method: A clinical trial, self-compared before and after treatment on 40 chronic urticaria patients examined at the Dermatology out-patient clinic of 103 Military Hospital from September 2021 to June 2022. Patients were treated with a 10mg oral dose of levocetirizine daily for four weeks. Urticaria activity score and quality of life score were recorded weekly. Result: The mean chronic urticaria patient's age was 42.27 ± 15.37. After 4 weeks of treatment, the UAS index decreased from 4.58 ± 1.01 at the beginning of treatment to 1.33 ± 1.33 at the end of therapy. The quality of life improved markedly more than those at the beginning of treatment, with a mean score of 31.50 ± 8.82. Forty-five percent of chronic urticaria patients had excellent response without symptoms after 4 weeks treated with a 10mg dose of levocetirizine therapy. The most common side effect was sedation (12.5%). Conclusion: 10mg oral levocetirizine therapy effectively controls symptoms of chronic urticaria.
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2. Phan Quang Đoàn, Nguyễn Văn Đĩnh và Lê Anh Tuấn (2008) Tình hình mắc bệnh mày đay, phù quincke trong cộng đồng dân cư Hà Nội năm 2008. Y học thực hành, 1 (641+642), tr. 52-55.
3. Nguyễn Thị Liên (2019) Nghiên cứu tỷ lệ nhiễm Helicobacter pylori ở bệnh nhân mày đay mạn và hiệu quả điều trị bằng phác đồ ba thuốc diệt vi khuẩn. Luận án Tiến sĩ, Viện Nghiên cứu Khoa học Y Dược lâm sàng 108.
4. Zuberbier T et al (2018) The EAACI/GA²LEN/ EDF/WAO guideline for the definition, classification, diagnosis and management of urticaria. Allergy, 73(7): 1393-1414.
5. Staevska M et al (2010) The effectiveness of levocetirizine and desloratadine in up to 4 times conventional doses in difficult-to-treat urticaria. Journal of Allergy and Clinical Immunology 125(3): 676-682.
6. Sarkar TK et al (2017) Effectiveness and safety of levocetirizine 10mg versus a combination of levocetirizine 5mg and montelukast 10mg in chronic urticaria resistant to levocetirizine 5mg: A double-blind, randomized, controlled trial. Indian J Dermatol Venereol Leprol 83(5): 561-568.
7. Thi HT et al (2019) The Efficacy of a Two-Fold Increase of H1-Antihistamine in the Treatment of Chronic Urticaria - the Vietnamese Experience. Open Access Maced J Med Sci 7(2): 259-263.
8. Sharma VK et al (2017) An open-label prospective clinical study to assess the efficacy of increasing levocetirizine dose up to four times in chronic spontaneous urticaria not controlled with standard dose. J Dermatolog Treat 28(6): 539-543.