Nghiên cứu hiệu quả điều trị bệnh trứng cá thông thường mức độ trung bình và nặng bằng isotretinoin và vitamin D đường uống

Abstract

Objective: To evaluate the results of acne vulgaris treatment with oral isotretinoin and vitamin D (Vit D). Subject and method: A controlled clinical trials, comparing the treatment effectiveness of 70 patients with moderate and severe Acne vulgaris. Patients were randomized to 2 groups, each of 35 patients, the study group used Isotretinoin 20mg/day and Vit D 1000UI/day, the control group only used Isotretinoin 20mg/day in 3 months treatment. Result: Both study group and control group had statistically significant differences in the severity of acne vulgaris and GAGS scores at 1 - 2 - 3 months after treatment compared with before treatment. After 3 months, both study and control groups showed very good, good and rather good improvement in more than 90% of patients. There was no statistically significant difference in GAGS score, disease severity, disease improvement as well as clinical side effects after 1 - 2 - 3 months of treatment between the 2 groups. Conclusion: In the treatment of moderate and severe acne vulgaris, oral Isotretinoin in combination with Vit D showed no difference in treatment results and side effects compared with using isotretinoin alone.