Đánh giá tác dụng phụ sớm của phác đồ hóa xạ trị triệt căn ở bệnh nhân ung thư thực quản 1/3 trên tại Bệnh viện Trung ương Quân đội 108

Abstract

Objective: To evaluate the early toxicities of curative chemoradiation regimen in upper third esophageal carcinoma. Subject and method: A descriptive study of 53 patients with stage II-III upper third esophageal carcinoma whom underwent curative chemoradiation regimen 60Gy/28 fractions and paclitaxel/carboplatin infusion weekly at Department of Radiation Oncology and Radiosurgery, 108 Military Central Hospital from May 2017 to January 2021. The patients’early adversed effects were evaluated according to CTCAE 4.0. Result: The rate of patients completed the treatment schedule was 79.2%. The early toxicities were often noted at 4^th and 5^th weeks of treatment and were mostly grade 1-2 as follows: Dermatitis 85%, esophagitis 85.3%, neutropenia 26.4%, anemia 20.8%, thrombocytopenia 11.3%. The grade 3-4 toxicities included: Grade 3 and 4 neutropenia 3.8% and 1.9%, accordingly; grade 3 dermatitis 3.8%. Conclusion: Curative chemoradiation with carboplatin/paclitaxel regimen for patients with upper third esophageal carcinoma resulted in high compliant rate and safety profile with mostly grade 1-2 toxicities.