Investigate vascular aging in patients with ischemic stroke

  • Đỗ Thị Tuyết Bệnh viện Trung ương Quân đội 108
  • Thạch Thị Ngọc Khanh Bệnh viện Trung ương Quân đội 108
  • Nguyễn Thị Loan Bệnh viện Trung ương Quân đội 108
  • Phạm Tiến Tuyên Bệnh viện Trung ương Quân đội 108
  • Nguyễn Thị Thủy Bệnh viện Trung ương Quân đội 108

Main Article Content

Keywords

Ischemic stroke, vascular aging

Abstract

Objective: To investigate the vascular aging and the correlation of this index with the clinical features and subclinical tests of patients with ischemic stroke. Subject and method: 99 patients with ischemic stroke at Stroke Center, 108 Military Central Hospital were enrolled, from 6/2020 to 5/2021. Patient characteristics, clinical information and vascular aging were analyzed. Result and conclusion: The mean of age was 57.5 ± 7.0 years (77.8% males). The mean of vascular aging was 73.9 ± 9.4 years that was higher than the mean of patient age (p<0.001). Compared to patients without hypertension, diabetes, lipid disorder, occlusion artery, NIHSS ≤ 6, and mRS 0 - 3, those with hypertension, diabetes, lipid disorder, occlusion artery, and mRS 4 - 6 had significantly higher vascular aging (p<0.05). Vascular aging was correlated with patient’s ages (r = 0.593, p<0.05), and mRS score at discharge (r = 0.276, p<0.05).

Article Details

References

1. GBD 2016 Neurology Collaborators (2019) Global, regional, and national burden of neurological disorders, 1990-2016: A systematic analysis for the Global Burden of Disease Study 2016. Lancet Neurol 18(5): 459-480.
2. Nilsson PM (2008) Early vascular aging (EVA): consequences and prevention. Vasc Health Risk Manag 4(3): 547-52.
3. Barber PA et al (2000) Validity and reliability of a quantitative computed tomography score in predicting outcome of hyperacute stroke before thrombolytic therapy. ASPECTS Study Group. Alberta Stroke Programme Early CT Score. Lancet 355(9216): 1670-1674.
4. Rankin J (1957) Cerebral vascular accidents in patients over the age of 60. II. Prognosis. Scott Med J 2(5): 200-215.
5. McPherson R et al (2006) Canadian Cardiovascular Society position statement recommendations for the diagnosis and treatment of dyslipidemia and prevention of cardiovascular disease. Can J Cardiol 22(11): 913-927.
6. Laurent S et al (2001) Aortic stiffness is an independent predictor of all-cause and cardiovascular mortality in hypertensive patients. Hypertension 37(5): 1236-1241.
7. Laurent S et al (2006) Expert consensus document on arterial stiffness: Methodological issues and clinical applications. Eur Heart J 27(21): 2588-2605.
8. Danaei G et al (2006) Global and regional mortality from ischaemic heart disease and stroke attributable to higher-than-optimum blood glucose concentration: Comparative risk assessment. Lancet 368(9548): 1651-1659.
9. Gąsecki D et al (2012) Pulse wave velocity is associated with early clinical outcome after ischemic stroke. Atherosclerosis 225(2): 348-352.