Adherence status to treatment and adherence-related factors on outpatients with hepatocellular carcinoma at 108 Military Central Hospital in 2021

  • Nguyễn Thị Loan Bệnh viện Trung ương Quân đội 108
  • Nguyễn Thị Ngọc Linh Bệnh viện Trung ương Quân đội 108
  • Nguyễn Ngọc Mai Bệnh viện Trung ương Quân đội 108
  • Phạm Thị Trang Bệnh viện Trung ương Quân đội 108
  • Chu Việt Anh Bệnh viện Trung ương Quân đội 108
  • Vũ Thị Hồng Bệnh viện Trung ương Quân đội 108
  • Lê Duy Cương Bệnh viện Trung ương Quân đội 108

Main Article Content

Keywords

Hepatocellular carcinoma, adherence to treatment, outpatients

Abstract

Objective: To evaluate status of adherence to treatment and adherence-related factors on outpatients with hepatocellular carcinoma (HCC) at 108 Military Central Hospital from January to July, 2021. Subject and method: A cross-sectional study was conducted on 384 over-18-years old outpatients with HCC. The adherence was determined via calculating score amount of 4 criteria: Adherence to chemotherapy medications, adherence to physical exercises, adherence to diet. We measured five non-adherence-related factors according to WHO, included: condition-related, patient-related, socio-economic-related, treatment-related and healthcare-system/provider-related factors. Result: The rate of adherence patients was 43.2%, in which, adherence to chemotherapy medications was 45.8%; adherence to diet was 51.6%; adherence to preventing rick factors: Giving up smoking (85.9%), adherence to virus hepatitis treatment (71.6%), non-alcoholic drink (62.0%); adherence to physical exercises (48.7%). The adherence-related factors (p<0.05) included: Difficulties for taking drugs, side effects of medications, finance, understanding the disease and treatment methods, the trust in physician. Conclusion: 43.2% of HCC outpatients were the adherence to treatment. The patients with better adherence were not difficulties for taking drugs; not side effects of medications; not financial leeway; having support of relatives and friend/neighbors; understanding well the disease, treatment methods and taking drugs; high level of trust in physician.

Article Details

References

1. Hà Văn Mạo (2006) Dịch tễ học và các yếu tố nguy cơ của ung thư gan nguyên phát. Nhà xuất bản Y học; 2, tr. 13-22.
2. Sabata E (2003) On behalf of the WHO. Adherence to long-term therapies: Evidence for action. Geneva: World Health Organization.
3. WHO (2010) Global Recommendations on Physical Activity for Health. WHO guidelines approved by the guidelines review committee, Geneva.
4. Selena ZK, Marta H, Jennifer CL (2017) Factors associated with medication non-adherence in patients with end-stage liver disease. Dig Dis Sci 62(2): 543–549.
5. Luciana K, Aline LC, Regiane SSM (2017) Adherence to BCLC recommendations for the treatment of hepatocellular carcinoma: Impact on survival according to stage. Clinics 72(8): 454-460.
6. Madhur G, Rafi K, Amanda B (2015) The impact of dietary regimen compliance on outcomes for head and neck cancer patients treated with definitive radiation therapy. American Society of Clinical Oncology 33(15). DOI: 10.1200/jco.2015.33.15_suppl.e17100.
7. Pfizer Corporation (2012) Awareness and survey on leaving drink of prescriptiondrugs [Internet]. Tokyo: Pfizer Corporation.
8. Van WH, Stuiver MM, Van HWH et al (2015) Effect of low-intensity physical activity and moderate- to high-intensity physical exercise during adjuvant chemotherapy on physical fitness, fatigue, and chemotherapy completion rates: Results of the paces randomized, Clinical Trial. J Clin Oncol 33: 1918-1927.
9. Rector TS, Venus PJ (2004) Do drug benefits help medicare beneficiaries afford prescribed drugs? Health Aff (Millwood) 23: 213–222.
10. DiMatteo MR (2004) Social support and patient adherence to medical treatment: A meta-analysis. Health Psychol 23: 207-218.