ISSN: 1859 - 2872
Dislay of STAT 1 and STAT 3 protein signals in hepatocellular carcinoma
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Abstract
Hepatocellular carcinoma (HCC) is characterized by many different factors, the inactivation of signaling pathways through overactivation of genes is one of the biomarkers in cancer. HCC is characterized by various factors, including inactivation of the STAT 1 and STAT 3 signaling pathways through overactivation of the STAT genes and disturbances in immune control. Objective: To evaluate the dislay of STAT 1 and STAT 3 protein signals in hepatocellular carcinoma. Subject and method: Determined the expression levels of two signals SAT 1 and STAT3 in HCC patients by Western blot method. Result: Both STAT1 and STAT3 proteins were expressed in HCC cells, and when STAT1 levels decreased, there was strongly phosphorylation of STAT3 Tyr 705 (pSTAT3 Tyr705) after 2 h of IFN-γ exposure but not long. When STAT3 levels decreased, IL-6 induced prolonged STAT1 signaling and interplay of STAT1 and STAT3 signaling in the presence of proinflammatory IL-6. Conclusion: STAT1 and STAT3 are important and potential biomarkers in early HCC diagnosis.
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References
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