ISSN: 1859 - 2872
Long term survival of radio frequency with Cool-tip electrode for hepatocellular carcinoma
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Abstract
Objective: To evaluate long term survival and predictive factors of percutaneous radiofrequency ablation with Cool-tip for the treatment of hepatocellular carcinoma (HCC). Subject and method: A prospective study involved 82 cirrhotic HCC patients (mean tumor size: 3.15 ± 1.07cm) underwent percutaneous RFA using Cool-tip RF electrode (COOL-TIP E SERRIES, COVIDIEN) at the 108 Military Central Hospital, from September 2012 to July 2020). The Kaplan-Meier curves and the multivariate Cox regression analysis were used to assess long term survival and the prognostic factors. Result: The 3-year, 4-year, 5-year, 6-year, 7-year cumulative survival rate were 90.2%, 84.1%, 37.8%, 34.1% and 18.3% respectively. Tumour free survival 3-year, 4-year, 5-year, 6-year were 64.6%, 35.3%, 8.5% and 2.4% respectively. At multivariate analysis, independent prognostic factors for survival rate were tumour size, number of tumour, Child-Pugh classification, meanwhile number of tumour and AFP response were the predictive factors for progression free survival. Conclusion: RFA with Cool-tip electrode is effective and result in long term survirval, especially for patients with a single tumor, tumour size < 3cm, and well-preserved liver function.
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References
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