Đặc điểm lâm sàng và hình ảnh xạ hình xương ở bệnh nhân ung thư biểu mô tế bào gan

Abstract

Objective: To evaluate clinical, laboratory features and relationship with bone metastasis among hepatocellular carcinoma (HCC) patients. Subject and method: A cross-sectional study was done on HCC patients treated at the 108 Military Central Hospital, from 7/2012 to 7/2015. Patients underwent the whole body bone scintigraphy about 3 hours after the intravenous injection of 15mCi of Tc-99m methylene diphosphonate. Result: 65 patients were recruited, including 58 males and 7 females, Mean age was 59 ± 12 years, range from 30 - 83 years old. The clinical symptoms including upper quadrant right pain, loss of appetite, bloating dyspepsia accounted for high percentage 95.4%, 86.5%, 86.5% respectively. The rate of patients with serum AFP ≥ 300UI/ml was 36.9%. The rate of patients who had slight elevation of liver enzymes and bilirubin level accounted for from 73.8 to 84.6%. Most patients had ≥ 2 tumors located in the right lobe or both lobes of liver. 76.6% of cases had tumor ≥ 3cm, portal vein thrombosis accounted for 49.2%. Bone metastases accounted for 32.3%, Bone lesions mainly located in vertebral columm and hip bones. Patients with serum AFP ≥ 300UI/ml had higher rate of bone metastasis compared with patients who had AFP < 300UI/ml. Conclusion: Bone metastasis is common among HCC patients and related to elevation of serum AFP ≥ 300UI/ml.