Khảo sát một số yếu tố liên quan đến tái phát và sống còn sau phẫu thuật cắt gan điều trị ung thư biểu mô tế bào gan

Abstract

Objective: To analyze recurrent rate, disease-free survival (DFS), overall survival (OS) and factors affecting recurrence, DFS and OS in patients with hepatocellular carcinoma (HCC) treated by liver resection. Subject and method: 4273 HCC patients treated by liver resection at Liver Tumor Department, Cho Ray Hospital, HoChiMinh City, Vietnam between January 2010 and December 2019 were enrolled in a retrospective study. Those patients were followed up until June 2021, with follow-up time is at least 18 months and at most 138 months. The prognostic significance of viral markers, AFP level, resection level and portal vein tumor thrombosis (PVTT) were evaluated by univariate analysis using the log-rank test and by multivariate analysis using the Cox proportional-hazards regression to determine the related factors affecting recurrence, DFS, OS. Result: Univariate analysis showed that viral markers, AFP level, resection level and PVTT were related to recurrence. Multivariate analysis using the Cox proportional-hazards regression showed that AFP level, resection level and PVTT were prognostic factors for DFS and OS. Conclusion: Factors predicting recurrence, DFS and OS are different and multifactorial. Close postoperative surveillance after liver resection on HCC patients is needed to improve outcome of HCC patients treated by liver resection.