ISSN: 1859 - 2872
Association between HER2, CD44, ALDH co-expression with endoscopic and histopathological characteristics in gastric adenocarcinoma
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Abstract
Objective: To analyze the relationship between immunohistochemical markers HER2, CD44, ALDH with endoscopic and histopathological characteristics in gastric adenocarcinoma. Subject and method: A cross-sectional descriptive study; prospective design on 107 patients with confirmed diagnosis of gastric adenocarcinoma and surgical resection of the tumor at K Hospital. Analysis of the relationship between HER2, CD44, ALDH and parameters. Result: Patients with intestinal type had the rate of simultaneous expression of all 3 markers at 14.1%, there was a difference in the concomitant expression of all 3 markers according to Lauren's histopathological characteristics, p<0.05. Patients with mucinous adenomas had the highest rate of concurrent expression of all 3 markers with 16.7%, there was a difference in the simultaneous expression of all 3 markers according to WHO histopathological characteristics, p<0.05. Conclusion: Simultaneous expression of HER2, CD44, ALDH is associated with factors such as Lauren's histopathological characteristics, WHO histopathological characteristics in gastric adenocarcinoma patients.
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References
2. Nguyen TP, Luu HN, Nguyen MVT et al (2020) Attributable causes of cancer in Vietnam. JCO Glob Oncol 6: 195-204.
3. Eldeen MA, Hashim A, Eid RA et al (2021) Molecular targeting of breast cancer stem cells: A promising strategy for management and eradication. European Journal of Molecular & Clinical Medicine 8(1): 1756-1768.
4. Takaishi S, Okumura T, Tu S et al (2009) Identification of gastric cancer stem cells using the cell surface marker CD44. Stem Cells 27(5): 1006-1020.
5. Nguyen PH, Giraud J, Staedel C et al (2016) All-trans retinoic acid targets gastric cancer stem cells and inhibits patient-derived gastric carcinoma tumor growth. Oncogene 35(43): 5619-5628.
6. Smyth EC, Verheij M, Allum W et al (2016) Gastric cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol 27(5): 38-49.
7. Nguyen PH, Giraud J, Chambonnier L et al (2017) Characterization of biomarkers of tumorigenic and chemoresistant cancer stem cells in human gastric carcinoma. Clin Cancer Res 23(6): 1586-1597.
8. Otaegi-Ugartemendia M, Matheu A, Carrasco-Garcia E (2022) Impact of cancer stem cells on therapy resistance in gastric cancer. Cancers (Basel) 14(6):1457.
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