ISSN: 1859 - 2872
¬Effect of botulinum toxin type A (Dysport®) injection combined with rehabilitation on gross motor function in children with spastic cerebral palsy
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Abstract
Objective: To evaluate the effect of botulinum toxin type A (BTA) injection in combination with rehabilitation on gross motor function in children with spastic type of cerebral palsy. Subject and method: Longitudinal intervention study with a control group. 140 eligible children with spastic cerebral palsy from 2 to 12 years old were recruited from the Rehabilitation Department of National Children’s Hospital from December 2015 to December 2017, and divided into two groups in our study. Result and conclusion: After 12 months of intervention, the mean of GMFCS scores in the study group decreased by 0.87 ± 0.56 (p<0.01). The mean scores in the control group decreased by 0.31 ± 0.47 (p<0.01). The mean difference of mean GMFCS scores after the intervention between the two group was 0.48 (p<0.001). Children with spastic cerebral palsy, who received BTA-injection in combination with rehabilitation achieved good and very good improvement which was 7.36 times higher than children who had only rehabilitation therapy (p<0.001).
Keywords: Spastic cerebral palsy, botulinum toxin type A, gross motor function.
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References
2. Trịnh Quang Dũng, Nguyễn Hữu Chút (2014) Đánh giá kết quả phục hồi chức năng bại não thể co cứng bằng tiêm dysport (Botulinum Toxin Type A) và các biện pháp phối hợp. Tạp chí Y học Thực hành 912, tr. 58-61.
3. Nguyễn Thi Hùng (2010) Nhận xét về 10 trường hợp co cứng cơ trong bại não điều trị bằng toxin botulinum. Tạp chí Y học TP. Hồ Chí Minh, tập 14, phụ bản số 1.
4. Blair E, Stanley FJ (1997) Issues in the classification and epidemiology of cerebral palsy. Ment Retard Dev Disabil Res Rev 3: 184-193.
5. Ade-Hall RA, Moore AP (2000) Botulinum toxin type A in the treatment of lower limb spasticity in cerebral palsy. Cochrane Database Syst Rev (2): CD001408.
6. Palisano R et al (1997) Development and reliability of a system to classify gross motor function in children with cerebral palsy. Dev Med Child Neurol 39(4): 214-223.
7. Carlos Henrique F et al (2009) Botulinum toxin type A in the treatment of lower limb spasticity In children with cerebral palsy. Arq Neuropsiquiatr 67(1): 62-68.
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