Nghiên cứu nồng độ vitamin D và IL-17 huyết thanh trước và sau điều trị và mối liên quan của chúng với biểu hiện lâm sàng ở bệnh nhân trứng cá thông thường mức độ trung bình và nặng

Abstract

Objective: To evaluate serum vitamin D and IL-17 levels before and after treatment with oral Isotretinoin and Vitamin D, and analyze their relationships with clinical features in patients with moderate and severe acne vulgaris. Subject and method: 70 patients with moderate and severe acne vulgaris treated as outpatients at Ho Chi Minh City Hospital of Dermato-Venereology, and 70 healthy controls. Prospective, controlled cross-sectional method. Result: Serum vitamin D and IL-17 levels in moderate and severe acne patients were significantly different from healthy controls and significantly related to sex, age, sunscreen using, but did not relate to the severity of acne. After treatment, serum vitamin D and IL-17 levels were significantly different from before treatment in both groups: Using oral isotretinoin in combination with Vit D and using isotretinoin alone. But there was no difference when comparing these 2 groups after treatment. Conclusion: Serum Vit D and IL-17 levels in patients with moderate and severe acne vulgaris were significantly different from healthy controls. There is a significant change in serum Vit D and IL-17 levels before and after treatment with oral isotretinoin and Vit D.