Nghiên cứu nồng độ alkaline phosphatase huyết tương bệnh nhân nhồi máu não

Abstract

Objective: To evaluate of changes in plasma alkaline phosphatase (ALP) of patients with ischemic stroke (IS) at 108 Military Central Hospital. Initial investigation of the prognostic role of plasma ALP for developing IS events. Subject and method: 70 healthy individuals and 120 IS patients that were treated at Stroke Center - 108 Military Central Hospital from 6/2021 to 12/2021. The participants were clinically examined, having CT scan or MRI of brain, taking ALP and biological indicators tests upon hospitalization. Result: The plasma ALP levels of patients with IS (258.94 ± 34.56U/L) were significant higher than those of control group (197.31 ± 16.25U/L), p<0.01. The cutoff threshold of ALP levels was 238U/l that could distinguish IS patients from control group with the area under ROC curve was 0.798; 95% confident interval: 0.651 - 0.962, p<0.01. Univariate analysis shown that individuals with elevated ALP levels had 1.72 fold increased risk of cerebral infarction compared with those with normal ALP concentrations (95% CI: 1.43 - 2.11, p<0.05). There was no association between plasma ALP levels and IS in multivariate analysis (OR = 1.084, 95% CI: 1.074 - 1.094, p>0.05). Conclusion: The cutoff threshold of ALP levels was 238U/l that could independently discriminate IS group from control group. ALP level was not an independent prognostic marker of IS, p>0.05.