ISSN: 1859 - 2872
Features of chest computed tomography image of invasive Aspergillus lung fungus treated at the National Lung Hospital on occasion 47 cases
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Abstract
Objective: To describe the characteristics of chest computed tomography (CT) imaging of Invasive Pulmonary Aspergillus (IPA) diseases with clinical signs, confirmed by laboratory tests. Subject and method: 47 patients were diagnosed with invasive Aspergillus lung fungus by 1 or from 2 methods: Microbiology (microscopy, identification culture); Immunological (Galactomanna antigen, Aspergillus LFD rapid test, 1,3-β-D-gluca antigen concentration); Indirect fungal identification test (IgG, IgE, IgM); molecular biology (real-time PCR), pathophysiology. Method: Retrospective, descriptive, cross-sectional study. Result: Average age 54 ± 14 years; male/female was 2/1; cough with phlegm (36.2%); shortness of breath (48.9%); fever (40.4%); hemoptysis (6.4%); duration of symptoms was mostly 1 - 3 weeks before admission; 100% of patients had underlying diseases, of which 63.8% had host factors of EORTC/MSG, the most were hematologic malignancies (34%) and prolonged use of corticosteroids (23.4%). Positive diagnostic techniques: Sputum culture (21/47 = 44.7%), culture of bronchoalveolar lavage/BAL (15/47 = 31.9%); pathology: Endoscopic bronchial biopsy (15/47 = 31.9%); transthoracic biopsy (11/47 = 23.4%); blood galactomannan test (12/47 = 25.5%); galactomannan BAL (2/47 = 4.3%), blood LFD (5/47 = 10.6%); LFD BAL (2/47 = 4.3%). Note/multiple-notes (66 - 70%), solidified (38.3 - 51.1%), cavity/multi-cavity (29%), glass opacity around nodule/halo (53.2 - 66%), thickening of airway wall (20%). Conclusion: Chest CT has an important role in orienting and supporting the diagnosis of invasive Aspergillus lung fungus.
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References
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