ISSN: 1859 - 2872
The apoB/apoA-I ratio and relationship with intracranial atherosclerosis in ischemic stroke patients
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Abstract
Objective: To evaluate concentrations of apolipoprotein A-I, apolipoprotein B, apolipoprotein B/apolipoprotein A-I ratio according to cerebral atherosclerosis in ischemic stroke patients. To determine the prognostic value of atherosclerotic stenosis, occlusion of intracranial arteries in ischemic stroke patients of the apoB/apoA-I ratio. Subject and method: 248 ischemic stroke patients (IS) were examined and treated at 108 Military Central Hospital from 10/2017 - 12/2019. The patient group were divided into 2 groups: large atherosclerostic artery stroke (n = 146) and small artery occlusive stroke (n = 102). Cross-sectional descriptive prospective study method. Patients were examined clinically, diagnosed with imaging and tested apoA-I, apoB, apoB/apoA-I ratio on admission. Result: The apoB concentration, apoB/apoA-I ratio of the intracranial atherosclerosis group was higher than that of the extracranial atherosclerosis group (1.34 ± 0.3g/l and 1.22 ± 0.27g/l; 1.19 ± 0.33 and 0.97 ± 0.35) with p<0.05. Patients with one site stenosis, occlusion had higher apoA-I concentration; apoB concentration, apoB/apoA-I ratio were lower than patients with multiple sites stenosis, occlusion with p<0.05 and p<0.01. The apoB concentration, apoB/apoA-I ratio were lowest in the group of moderate stenosis to severe stenosis and highest in the occlusion group. The apoA-I concentration was inversely correlated with the degree of stenosis and occlusion (r = -0.34, p<0.01). The apoB concentration, the apoB/apoA-I ratio were positively correlated with the degree of cerebral artery stenosis, occlusion (r = 0.35, p<0.01 and r = 0.41, p<0.01). Multivariate analysis of intracranial atherosclerosis group: apoB/apoA-I ratio with OR = 3.543; 95% CI (1.074 - 11.632); p<0.05. The cut-off value was 0.965 (sensitivity: 63%; specificity: 55%). Conclusion: ApoA-I concentration, apoB concentration, apoB/apoA-I ratio change according to the state of cerebral atherosclerosis. The apoB/apoA-I ratio is an independent predictor of intracranial atherosclerosis in ischemic stroke patients.
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References
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