Association of IL36RN and CARD14 mutations with some laboratory findings in patients with pustular psoriasis in Vietnam

  • Nguyen Ngoc Trai Pham Ngoc Thach Medical University

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Keywords

Pustular psoriasis, gene mutation, IL36RN, CARD14, laboratory findings

Abstract

Objective: To investigate the relationship between IL36RN and CARD14 gene mutations with some laboratory findings of pustular psoriasis. Subject and method: A descriptive cross-sectional study on 64 patients with pustular psoriasis at Ho Chi Minh City (HCMC) Dermatology Hospital and Hanoi Central Institute of Dermatology. Blood samples were collected for laboratory testing: White blood cells, CRP, serum albumin. Then other blood samples (2ml) were taken to conduct sequencing at the Center for Molecular Biomedicine, University of Medicine and Pharmacy at HCMC to identify mutations in the IL36RN and CARD14 genes. Result: The rate of leukocytosis ≥ 15.000/mm3 was significantly higher in patients with the c.1641C>T variation of the CARD14 gene. The incidence of hypoalbuminemia < 3.8g/dL was meaningly lower in patients with the c.1753G>A variant of the CARD14 gene. Conclusion: Mutations of CARD14 gene were associated with some laboratory changes of pustular psoriasis such as: Leukocytosis ≥ 15.000/mm3, hypoalbuminemia < 3.8g/dL.

Article Details

References

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Published
Mar 10, 2022
DOI: https://doi.org/10.52389/ydls.v17i2.1148
Issue
Volume 17 - No 2/2022
Section
Articles
How to Cite
TraiN. N. (2022). Association of IL36RN and CARD14 mutations with some laboratory findings in patients with pustular psoriasis in Vietnam. Tạp Chí Y Dược lâm sàng 108, 17(2). https://doi.org/10.52389/ydls.v17i2.1148