ISSN: 1859 - 2872
Association of IL36RN and CARD14 mutations with some clinical manifestations in patients with pustular psoriasis in Vietnam
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Abstract
Objective: To investigate the association of the IL36RN and CARD14 mutations with some clinical features of patients with pustular psoriasis. Subject and method: A descriptive cross-sectional study included 64 patients with pustular psoriasis at Ho Chi Minh City (HCMC) Dermatology Hospital and Hanoi Central Institute of Dermatology. The patients' history and clinical examination were collected. Blood samples (2ml) were taken for sequencing to identify mutations in the IL36RN and CARD14 genes at the Center for Molecular Biomedicine, University of Medicine and Pharmacy at HCMC. Result: The c.115+6T>C variant (IL36RN) was associated with pustular psoriasis alone. The rate of history of psoriasis vulgaris in the CARD14 alone group was higher than the IL36RN alone and the IL36RN + CARD14 group. Two variants c.115+6T>C and c.227C>T (IL36RN) were associated with fever ≥ 38.5oC. c.115+6T>C was associated with geographic tongue. Conclusion: Mutation of IL36RN were associated with some clinical symptoms of pustular psoriasis: History of psoriasis vulgaris, fever ≥ 38.5oC, geographic tongue.
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References
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