ISSN: 1859 - 2872
Evaluation of the effects of diabetes mellitus-causing streptozotocin on Vietnamese Swiss mice model
Main Article Content
Keywords
Streptozotocin (STZ), diabetes mellitus, Swiss mice, pancreas
Abstract
Objective: To evaluate the effects of STZ on Swiss mice model in Vietnam by evaluating the hematological, biochemical and histological indicators of liver, kidney and pancreas in Swiss male mice after 5 weeks of injection. Subject and method: STZ was dissolved in a citrate buffer (pH = 4.5), injected into the peritoneum at two STZ- low (< 80mg/kg) and STZ-high (≥ 80mg/kg), after 10 weeks of follow-up. Result: Obtained with STZ-high did not cause disease successfully. The dose of STZ-low is repeated 4 times as a successful diabetes dose (reaching 70%) for the Swiss mice breed in Vietnam. Conclusion: In this study, diabetes in Swiss mice at lower doses was more successful than in high doses and no deaths occurred
Article Details
References
1. Bai Q, Han K, Dong K et al (2020) Potential applications of nanomaterials and technology for diabetic wound healing. Int J Nanomedicine 15: 9717-9743.
2. Wild S, Roglic G, Green A et al (2004) Global prevalence of diabetes estimates for the year 2000 and projections for 2030. Diabetes Care 27: 1047-1053.
3. Lenzen S (2007) Alloxan and streptozotocin diabetes. [http://www.saw-leipzig.de/endo_07-lenzen_3.pdf].
4. Minaiyan M, Ghannadi A, Movahedian A, Hakim-Elahi I (2014) Effect of Hordeum vulgare L (Barley) on blood glucose levels of normal and STZ-induced diabetic rats. Research in Pharmaceutical Sciences 9(3): 173-178.
5. Kato A, Minoshima Y, Yamamoto J, Adachi I et al (2008) Protective effects of dietary chamomile tea on diabetic complications. J. Agric. Food Chemistry 56: 8206-8211.
6. Emam MA (2012) Comparative evaluation of antidiabetic activity of Rosmarinus officinalis L. and Chamomile recutita in streptozotocin induced diabetic rats. Agric.Biol.J.N.Am 3(6): 247-252.
7. Tenpe CR, Yeole PG (2009) Comparative evaluation of antidiabetic activity of some marketed polyherbal formulations in alloxan induced diabetic rats. International Journal of Pharm Tech Research 1(1): 43-49.
8. Mealey BL, Ocampo GL (2007) Diabetes mellitus and periodontal disease. Periodontology 44: 127-153.
9. Low A, Nickander K, Tritschler J (1977) The role of oxidative stress and antioxidant treatment in experimental diabetic neuropathy. Diabetes 46: 38-41.
10. Arora S, Ojha S, Vohora D (2009) Characterisation of streptozotocin induced diabetes mellitus in swiss albino mice. Global J Pharmacol 3: 81-84.
11. Akindele O, Babatunde A, Chinedu F et al (2012) Rat model of food induced non-obese-type 2 diabetes mellitus; comparative pathophysology and histopathology. International Journal of Physiology, Pathophysiology and Pharmacology 4(1): 51-58.
12. Ayman MM (2013) Hematological alterations in diabetic rats - Role of adipocytokines and effect of citrus flavonoids. EXCLI J 12: 647–657.
13. Chen LN, Sun Q, Liu SQ et al (2015) Erythropoietin improves glucose metabolism and pancreatic β-cell damage in experimental diabetic rats. Molecular Medicine Reports 5391-5398.
14. Stookey JD, Burg M, Sellmeyer DE et al (2007) A proposed method for assessing plasma hypertonicity in vivo. European Journal of Clinical Nutrition 61: 143-146.
15. Domenico ID, Ward DM, Kaplan J (2008) Regulation of iron acquisition and storage: Consequences for iron-linked disorders. Nat Rev Mol Cell Biol 9: 72-81.
16. Hotamisligil G (2006) Inflammation and metabolic disorders. Nature 444: 860-867.
17. Shurtz-Swirski R, Sela S, Herskovits AT et al (2004) Involvement of peripheral polymorphonuclear leukocytes in oxidative stress and inflammation in type 2 diabetic patients. Diabetes Care 24: 104-110.
18. Pertynska-Marczewska M, Kiriakidis S, Wait R, et al. (2004) Advanced glycation end products upregulate angiogenic and pro-inflammatory cytokine production in human monocyte/macrophages. Cytokine 28: 35-47.
19. Korpinen E, Groop P, Fagerudd J et al (2001) Increased secretion of TGF-beta1 by peripheral blood mononuclear cells from patients with type 1 diabetes mellitus with diabetic nephropathy. Diabet Med 18: 121-125.
20. Kedziora-Kornatowska K (1999) Production of superoxide and nitric oxide by granulocytes in non-insulin-dependent diabetic patients with and without diabetic nephropathy. IUBMB Life 48: 359-362.
21. Shanmugam N, Reddy M, Guha M, Natarajan R. (2003) High glucose-induced expression of proinflammatory cytokine and chemokine genes in monocytic cells. Diabetes 52: 1256-1264.
22. Peelman F, Waelput W, Iserentant H, et al. (2004) Leptin: Linking adipocyte metabolism with cardiovascular and autoimmune diseases. Progress in Lipid Research 43: 283-301.
23. Frühbeck G (2006) Intracellular signalling pathways activated by leptin. Biochem J 393: 7-20.
24. Baumann H, Morella KK, White DW et al (1996) The full-length leptin receptor has signaling capabilities of interleukin 6-type cytokine receptors. Proc Natl Acad Sci USA 93: 8374-8378.
25. Kozlov I, Novitski V, Baìkov A (1995) Kinetics of blood leukocytes in mice with alloxan diabetes. Biull Eksp Biol Med 120: 33-35.
26. Koga T, Keiko M, Terao J (1980) Protective effet of vitamin E analog, phosphatidylchromanol, against oxidative hemolysis of human erythrocytes. Lipids 33.
27. Yakhchalian N, Mohammadian N, Hatami K et al (2018) Hematological and serum biochemical analysis of streptozotocin-Induced insulin dependent diabetes mellitus in male adult wistar rats. bioRxiv preprint first posted online.
28. Rakieten N, Rakieten ML, Nadkarni MV (1963) Studies on the diabetogenic action of streptozotocin (NSC-37917). Cancer Chemother Rep 29: 91-98.
29. Szkudelski T (2001) The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas. Physiol Res 50(6): 537-546.
30. Poretsky L (2010) Principles of diabetes mellitus. Boston, MA, USA: Springer.
31. Palm F, Ortsater H, Hansell P, Liss P, Carlsson PO (2004) Differentiating between effects of streptozotocin per se and subsequent hyperglycemia on renal function and metabolism in the streptozotocin-diabetic rat model. Diabetes Metab Res Rev 20(6): 452-459.
32. Rauter AP, Martins A, Borges C et al (2010) Antihyperglycaemic and protective effects of flavonoids on streptozotocin-induced diabetic rats. Phytother Res 24(2): 133-138.
33. Nidal a Qinna, Adnan a Badwan (2015) Impact of streptozotocin on altering normal glucose homeostasis during insulin testing in diabetic rats compared to normoglycemic rats. Drug Design, Development and Therapy 9: 2515-2525.
34. Houstis N, Rosen E, Lander E (2006) Reactive oxygen species have a causal role in multiple forms of insulin resistance. Nature 440(7086): 944-948.
2. Wild S, Roglic G, Green A et al (2004) Global prevalence of diabetes estimates for the year 2000 and projections for 2030. Diabetes Care 27: 1047-1053.
3. Lenzen S (2007) Alloxan and streptozotocin diabetes. [http://www.saw-leipzig.de/endo_07-lenzen_3.pdf].
4. Minaiyan M, Ghannadi A, Movahedian A, Hakim-Elahi I (2014) Effect of Hordeum vulgare L (Barley) on blood glucose levels of normal and STZ-induced diabetic rats. Research in Pharmaceutical Sciences 9(3): 173-178.
5. Kato A, Minoshima Y, Yamamoto J, Adachi I et al (2008) Protective effects of dietary chamomile tea on diabetic complications. J. Agric. Food Chemistry 56: 8206-8211.
6. Emam MA (2012) Comparative evaluation of antidiabetic activity of Rosmarinus officinalis L. and Chamomile recutita in streptozotocin induced diabetic rats. Agric.Biol.J.N.Am 3(6): 247-252.
7. Tenpe CR, Yeole PG (2009) Comparative evaluation of antidiabetic activity of some marketed polyherbal formulations in alloxan induced diabetic rats. International Journal of Pharm Tech Research 1(1): 43-49.
8. Mealey BL, Ocampo GL (2007) Diabetes mellitus and periodontal disease. Periodontology 44: 127-153.
9. Low A, Nickander K, Tritschler J (1977) The role of oxidative stress and antioxidant treatment in experimental diabetic neuropathy. Diabetes 46: 38-41.
10. Arora S, Ojha S, Vohora D (2009) Characterisation of streptozotocin induced diabetes mellitus in swiss albino mice. Global J Pharmacol 3: 81-84.
11. Akindele O, Babatunde A, Chinedu F et al (2012) Rat model of food induced non-obese-type 2 diabetes mellitus; comparative pathophysology and histopathology. International Journal of Physiology, Pathophysiology and Pharmacology 4(1): 51-58.
12. Ayman MM (2013) Hematological alterations in diabetic rats - Role of adipocytokines and effect of citrus flavonoids. EXCLI J 12: 647–657.
13. Chen LN, Sun Q, Liu SQ et al (2015) Erythropoietin improves glucose metabolism and pancreatic β-cell damage in experimental diabetic rats. Molecular Medicine Reports 5391-5398.
14. Stookey JD, Burg M, Sellmeyer DE et al (2007) A proposed method for assessing plasma hypertonicity in vivo. European Journal of Clinical Nutrition 61: 143-146.
15. Domenico ID, Ward DM, Kaplan J (2008) Regulation of iron acquisition and storage: Consequences for iron-linked disorders. Nat Rev Mol Cell Biol 9: 72-81.
16. Hotamisligil G (2006) Inflammation and metabolic disorders. Nature 444: 860-867.
17. Shurtz-Swirski R, Sela S, Herskovits AT et al (2004) Involvement of peripheral polymorphonuclear leukocytes in oxidative stress and inflammation in type 2 diabetic patients. Diabetes Care 24: 104-110.
18. Pertynska-Marczewska M, Kiriakidis S, Wait R, et al. (2004) Advanced glycation end products upregulate angiogenic and pro-inflammatory cytokine production in human monocyte/macrophages. Cytokine 28: 35-47.
19. Korpinen E, Groop P, Fagerudd J et al (2001) Increased secretion of TGF-beta1 by peripheral blood mononuclear cells from patients with type 1 diabetes mellitus with diabetic nephropathy. Diabet Med 18: 121-125.
20. Kedziora-Kornatowska K (1999) Production of superoxide and nitric oxide by granulocytes in non-insulin-dependent diabetic patients with and without diabetic nephropathy. IUBMB Life 48: 359-362.
21. Shanmugam N, Reddy M, Guha M, Natarajan R. (2003) High glucose-induced expression of proinflammatory cytokine and chemokine genes in monocytic cells. Diabetes 52: 1256-1264.
22. Peelman F, Waelput W, Iserentant H, et al. (2004) Leptin: Linking adipocyte metabolism with cardiovascular and autoimmune diseases. Progress in Lipid Research 43: 283-301.
23. Frühbeck G (2006) Intracellular signalling pathways activated by leptin. Biochem J 393: 7-20.
24. Baumann H, Morella KK, White DW et al (1996) The full-length leptin receptor has signaling capabilities of interleukin 6-type cytokine receptors. Proc Natl Acad Sci USA 93: 8374-8378.
25. Kozlov I, Novitski V, Baìkov A (1995) Kinetics of blood leukocytes in mice with alloxan diabetes. Biull Eksp Biol Med 120: 33-35.
26. Koga T, Keiko M, Terao J (1980) Protective effet of vitamin E analog, phosphatidylchromanol, against oxidative hemolysis of human erythrocytes. Lipids 33.
27. Yakhchalian N, Mohammadian N, Hatami K et al (2018) Hematological and serum biochemical analysis of streptozotocin-Induced insulin dependent diabetes mellitus in male adult wistar rats. bioRxiv preprint first posted online.
28. Rakieten N, Rakieten ML, Nadkarni MV (1963) Studies on the diabetogenic action of streptozotocin (NSC-37917). Cancer Chemother Rep 29: 91-98.
29. Szkudelski T (2001) The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas. Physiol Res 50(6): 537-546.
30. Poretsky L (2010) Principles of diabetes mellitus. Boston, MA, USA: Springer.
31. Palm F, Ortsater H, Hansell P, Liss P, Carlsson PO (2004) Differentiating between effects of streptozotocin per se and subsequent hyperglycemia on renal function and metabolism in the streptozotocin-diabetic rat model. Diabetes Metab Res Rev 20(6): 452-459.
32. Rauter AP, Martins A, Borges C et al (2010) Antihyperglycaemic and protective effects of flavonoids on streptozotocin-induced diabetic rats. Phytother Res 24(2): 133-138.
33. Nidal a Qinna, Adnan a Badwan (2015) Impact of streptozotocin on altering normal glucose homeostasis during insulin testing in diabetic rats compared to normoglycemic rats. Drug Design, Development and Therapy 9: 2515-2525.
34. Houstis N, Rosen E, Lander E (2006) Reactive oxygen species have a causal role in multiple forms of insulin resistance. Nature 440(7086): 944-948.
Article Sidebar
Published
Apr 1, 2021
Section
Articles
How to Cite
HươngN. V., ThuN. T. M., LongL. H., ViênH. S., LinhN. N. M., & HiếuN. N. (2021). Evaluation of the effects of diabetes mellitus-causing streptozotocin on Vietnamese Swiss mice model. Tạp Chí Y Dược lâm sàng 108, 16(DB4). https://doi.org/10.52389/ydls.v16iDB4.1020