Thực trạng sử dụng vancomycin tại Bệnh viện Trung ương Quân đội 108

Abstract

Objective: To describe ovancomycin use at 108 Military Central Hospital. Subject and method: A retrospective study was conducted on 61 medical records with vancomycin use at 108 Military Central Hospital from January 2020 to June 2020. Result: Mean age of patients was 59.9 years, the proportion of male patients was 75.4%. Discharge outcome: 68.9% with complete or partial recovery; 29.5% with death or worse outcome. Vancomycin was mainly prescribed empirically (90% with empirical indications and 10% with definitive indications). Microbiology tests were indicated in 96.7% of patients, of which 72.1% patients had positive results. Staphylococcus aureus was the most common gram (+) pathogen, of which 59.1% was MRSA. Loading dose was not used in 90% of patients. The most common maintenance dosing regimen was 1g every 12 hours (59.7%). However, this regimen was used on patients with very wide range of renal function (Clcr varied from 15.8ml/min to 155.3ml/min). Nephrotoxicity was occurred in 15 of 61 patients (24.6%), 13 patients of whom used concomitant medications with nephrotoxicity. Conclusion: The majority of patients weren’t received the loading dose (90%). The common maintenance dosing regimen was 1g every 12 hours, which was indicated in patients with various renal function (Clcr varied from 15.8ml/min to 155.3ml/min). The result of the study was very important basis for the implementation of a protocol for therapeutic monitoring of vancomycin.