ISSN: 1859 - 2872
Amyloidosis of the colon mimicking an acute ulcerative colitis flare: A case report
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Keywords
Ulcerative colitis, amyloidosis, reactive amyloidosis, light chain amyloidosis
Tóm tắt
The 2 most common types of amyloidosis are light chain (AL) that is associated with plasma cell dyscrasias and reactive (AA) that is associated with chronic inflammatory conditions. We report a 65-year-old man who presented with recurrent bloody diarrhea and anorexia that had been misdiagnosed as an ulcerative colitis (UC). Colonoscopy and detailed physical examination revealed features suspicious for amyloidosis. Bone marrow aspiration showed multiple myeloma and AL amyloidosis. This case demonstrates the importance of generating a broad differential and the pivotal role of physical examination and endoscopic findings in diagnosing uncommon diseases.
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Các tài liệu tham khảo
1. Ebert EC, Nagar M (2008) Gastrointestinal manifestations of amyloidosis. Am J Gastroenterol 103(3): 776-787.
2. Kanuru R, Stanich PP, Meyer MM (2014) Colonic complications from gastrointestinal amyloidosis. Austin J Gastroenterol 1(5): 1023.
3. Casad DE, Bocian JJ (1965) Primary systemic amyloidosis simulating acute idiopathic ulcerative colitis: Report of a case. Am J Dig Dis 10: 63-74.
4. Rahman N, Toqeer M, Hawley I et al (2011) Primary systemic amyloidosis presenting as idiopathic inflammatory colitis. BMJ Case Rep 2011: bcr0820114596.
5. Janczewska I, Mejhert M, Hast R et al (2004) Primary AL amyloidosis, ulcerative colitis and collagenous colitis in a 57-year-old woman: A case study. Scand J Gastroenterol 39(12):1306-1309.
6. Menke DM, Kyle RA, Fleming CR (1993) Symptomatic gastric amyloidosis in patients with primary systemic amyloidosi. Mayo Clin Proc 68(8): 763-767.
7. Greenstein AJ, Sachar DB, Panday AK et al (1992) Amyloidosis and inflammatory bowel disease. A 50-year experience with 25 patient. Medicine (Baltimore) 71(5): 261-270.
8. Yamada M, Hatakeyama S, Tsukagoshi H (1985) Gastrointestinal amyloid deposition in AL (primary or myeloma-associated) and AA (secondary) amyloidosis: Diagnostic value of gastric biopsy. Hum Pathol 16(12): 1206-1211.
9. Iida T, Yamano H, Nakase H (2018) Systemic amyloidosis with gastrointestinal involvement: Diagnosis from endoscopic and histological views. J Gastroenterol Hepatol 33(3): 583-590.
10. Cho SH, Kim SW, Kim WC (2013) Hemorrhagic bullous colitis in a patient with multiple myeloma. Endoscopy 45(Suppl 2 UCTN): 157-158.
2. Kanuru R, Stanich PP, Meyer MM (2014) Colonic complications from gastrointestinal amyloidosis. Austin J Gastroenterol 1(5): 1023.
3. Casad DE, Bocian JJ (1965) Primary systemic amyloidosis simulating acute idiopathic ulcerative colitis: Report of a case. Am J Dig Dis 10: 63-74.
4. Rahman N, Toqeer M, Hawley I et al (2011) Primary systemic amyloidosis presenting as idiopathic inflammatory colitis. BMJ Case Rep 2011: bcr0820114596.
5. Janczewska I, Mejhert M, Hast R et al (2004) Primary AL amyloidosis, ulcerative colitis and collagenous colitis in a 57-year-old woman: A case study. Scand J Gastroenterol 39(12):1306-1309.
6. Menke DM, Kyle RA, Fleming CR (1993) Symptomatic gastric amyloidosis in patients with primary systemic amyloidosi. Mayo Clin Proc 68(8): 763-767.
7. Greenstein AJ, Sachar DB, Panday AK et al (1992) Amyloidosis and inflammatory bowel disease. A 50-year experience with 25 patient. Medicine (Baltimore) 71(5): 261-270.
8. Yamada M, Hatakeyama S, Tsukagoshi H (1985) Gastrointestinal amyloid deposition in AL (primary or myeloma-associated) and AA (secondary) amyloidosis: Diagnostic value of gastric biopsy. Hum Pathol 16(12): 1206-1211.
9. Iida T, Yamano H, Nakase H (2018) Systemic amyloidosis with gastrointestinal involvement: Diagnosis from endoscopic and histological views. J Gastroenterol Hepatol 33(3): 583-590.
10. Cho SH, Kim SW, Kim WC (2013) Hemorrhagic bullous colitis in a patient with multiple myeloma. Endoscopy 45(Suppl 2 UCTN): 157-158.