Case report: Hereditary angioedema treated with fresh frozen plasma

Tóm tắt

Hereditary angioedema (HAE) is a rare autosomal dominant disease, characterized by recurrence swelling of the skin or mucosal tissue, and may cause airway obstruction. It is caused by C1-esterase inhibitor (C1-INH) deficiency, or dysfunction of C1-INH, therefore increased bradykinin and kallikrein production, which causes vasodilation, increases vascular permeability and localized fluid extravasation results in angioedema. The current recommendation for the treatment of an acute attack of HAE is with C1-INH, or synthetic bradykinin receptor antagonist. However, these drugs are not currently available in Vietnam, and the price is very expensive. Frozen fresh plasma is considered a safe alternative for patients because of its rapid and cheap effectiveness.