ISSN: 1859 - 2872
Predictors for acute kidney injury in patients with sepsis and septic shock
Main Article Content
Keywords
Tóm tắt
Objective: This study aimed to determine the risk factors for acute kidney injury (AKI) in patients with sepsis and septic shock. Subject and method: A prospective descriptive study with longitudinal follow-up of 201 patients with sepsis and septic shock admitted to Emergency Department - 108 Military Central Hospital. Result: The proportion of patients with AKI was 64.7%. In univariate analysis of risk factors for AKI, six potential risk factors identified: Hypertension, APACHE II score ≥ 20, SOFA score > 8, MOD score >8, lactate ≥2mmol/L, and HCO3- < 15mmol/L. However, in multivariate analysis, only hypertension, APACHE II score ≥ 20, and SOFA score > 8 emerged as independent risk factors for AKI. Conclusion: In patient with sepsis and septic shock, hypertension, APACHE II score ≥ 20 and the SOFA score > 8 were the key risk factors for acute kidney injury.
Article Details
Các tài liệu tham khảo
2. Peerapornratana S, Manrique-Caballero CL, Gómez H, Kellum JA (2019) Acute kidney injury from sepsis: Current concepts, epidemiology, pathophysiology, prevention and treatment. Kidney Int. 96(5): 1083-1099. doi:10.1016/j.kint.2019.05.026.
3. Rhodes A, Evans LE, Alhazzani W, et al (2017) Surviving sepsis campaign: International guidelines for management of sepsis and septic shock: 2016. Crit Care Med 45: 486-552.
4. Khwaja A (2012) KDIGO clinical practice guidelines for acute kidney injury. Nephron Clin Pract 120(4):c179-84. doi: 10.1159/000339789.
5. Liu J, Xie H, Ye Z, Li F, Wang L (2020) Rates, predictors, and mortality of sepsis-associated acute kidney injury: a systematic review and meta-analysis. BMC NephrolM 21(1): 318. doi: 10.1186/s12882-020-01974-8.
6. Deng J, Li L, Feng Y, Yang J (2023) Comprehensive management of blood pressure in patients with septic AKI. J Clin Med 12(3). doi:10.3390/jcm12031018.
7. Pinheiro KHE, Azêdo FA, Areco KCN, Laranja SMR (2019) Risk factors and mortality in patients with sepsis, septic and non septic acute kidney injury in ICU. J Bras Nefrol 41(4): 462-471. doi:10.1590/2175-8239-jbn-2018-0240.
8. Aiying Z (2019) Risk factors of acute kidney injury in patients with emergency sepsis. Pract Clin J Integr Tradit Chin West Med 19.
9. Liu H, Hou S, Tian X (2023) Risk factors of sepsis associated acute kidney injury in patients with sepsis: A meta-analysis. Intensive Care Research 3(2): 163-170. doi: 10.1007/s44231-023-00034-7.
10. Van den Akker JP, Egal M, Groeneveld AB (2013) Invasive mechanical ventilation as a risk factor for acute kidney injury in the critically ill: a systematic review and meta-analysis. Crit Care 17(3): 98. doi: 10.1186/cc12743.
11. Wang X, Jiang L, Wen Y et al (2014) Risk factors for mortality in patients with septic acute kidney injury in intensive care units in Beijing, China: a multicenter prospective observational study. Biomed Res Int 2014: 172620. doi:10.1155/2014/172620.