Evaluate the clinical manifestations, laboratory findings, and treatment approaches in patients with hypertriglyceridemia-induced acute pancreatitis

Tóm tắt

Objective: This study aimed to evaluate the clinical manifestations, laboratory findings, and treatment outcomes in patients diagnosed with hypertriglyceridemia-induced acute pancreatitis (HTG-AP). Subject and method: A retrospective, cross-sectional analysis was conducted on 132 patients with HTG-AP. Data on demographics, clinical symptoms, laboratory results, and treatment methods were collected within the first 24 hours of admission. Result: The mean age of patients was 44.7 ± 8.0 years, with a male predominance (76.5%). The most affected age group was 40-60 years (68.2%). Abdominal pain was a universal symptom, observed in 100% of patients. The median triglyceride level was 41.58mmol/L, with the highest recorded value reaching 205mmol/L. Common laboratory findings included leukocytosis and hyponatremia. The mortality rate was low at 0.8%. Antibiotics were administered to more than 60% of patients, while less than 30% received pain management medication. The most common triglyceride-lowering intervention was insulin (39.4%), followed by plasmapheresis (12.9%). Conclusion: The findings emphasize the need for cautious use of antibiotics to prevent resistance and highlight the importance of early recognition and appropriate treatment strategies in managing HTG-AP.