Surveying the changes in serum ubiquitin C-terminal hydrolase-L1 levels in severe traumatic brain injury patients

Tóm tắt

Objective: To investigate the change in serum ubiquitin C-terminal hydrolase-L1 protein (UCH-L1) levels in severe traumatic brain injury patients. Subject and method: Thirty-nine patients with severe traumatic brain injury were treated at the surgical critical care department, 103 Military Hospital. The patients were treated to the protocol, and information was collected in the medical records for research and testing. UCH-L1 at time T₀, T₁, T₂, T₃, T₄ and T₅. A prospective cohort study. Result: Serum UCH-L1 concentration gradually increased from T₀ (9.18ng/mL) to T₁ (11.59ng/mL) and peaked at T₂ (19.9ng/mL), then gradually decreased over time. The median serum UCH-L1 concentration in the surviving group was constantly lower than in the death group. The biggest difference observed at T₁ (10.47ng/mL and 46.76ng/mL), however, was not statistically significant with p=0.063, while the difference was statistically significant at T₃, T₄, and T₅. Conclusion: Serum UCH-L1 levels in patients with severe TBI increased gradually from T₀ to T₁ and peaked at T₂, then gradually decreased at T₅. Serum UCH-L1 levels in the surviving group were constantly lower than those in the death group, but there was no significant difference between T₀, T₁, and T₂, whereas at points between T3, T4, and T5, the difference was statistically significant.