ISSN: 1859 - 2872
Effect of botulinum toxin type A (Dysport®) injection combined with rehabilitation on improving the dynamic spastic equinus foot in children with spastic cerebral palsy
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Objective: To evaluate the efficacy of botulinum toxin type A (BTA) injection in combination with rehabilitation on improving the dynamic spastic equinus foot in children with spastic cerebral palsy. Subject and method: Longitudinal interventional study with a control group. 140 eligible children with spastic cerebral palsy from 2 to 12 years old who were recruited from the Rehabilitation Department of National Children’s Hospital from December 2015 to December 2017. Result: After 12 months of the treatment, the mean MAS scores of the gastrocnemius-soleus of the intervention group decreased by 1.39 ± 0.63 (p<0.01), and the passive ankle range of motion (ankle-PROM) was increased by 16.66 ± 11.99° (p<0.01), while the mean MAS scores of the control group decreased by 0.15 ± 0.34° (p<0.01), and ankle-PROM was increased by 3.10 ± 7.38° (p<0.01). The mean difference of mean MAS scores at 12 months after treating between both groups was -1.07 (p<0.01), and the mean difference of mean ankle-PROM was 11.69° (p<0.01). Conclusion: Botulinum toxin type A (Dysport®) - injection combined with rehabilitation improved muscles tone, increasing passive ankle range of motion, and improving on lower limb motor function in children with spastic cerebral palsy.
Keywords: Spastic cerebral palsy, botulinum toxin type A, spastic equinus foot.
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Các tài liệu tham khảo
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