Epidermal growth factor receptor mutations in non-small cell lung cancer patients from a single institution in Vietnam

Tóm tắt

Objective: The purpose of this study was to evaluate the epidermal growth factor receptor (EGFR) mutations and relationship with some clinical, paraclinical characteristics in non-small cell lung cancer (NSCLC) patients in 108 Military Central Hospital, Vietnam. Subject and method: This is a prospective study. Tumor tissue samples were collected from 500 NSCLC patients from Jan 2015 to Jan 2018. DNA was extracted from tissue samples and examined for EGFR mutations by a peptide nucleic acid (PNA)-locked nucleic acid (LNA) polymerase chain reaction (PCR) clamp-based detection test. Result: The patient’s mean age was 63.02 ± 9.6 years old and male/female ratio was near 4/1. Histology showed 80% of adenocarcinoma, 3.6% of squamous cell carcinoma, 0.8% of large cell carcinoma, 0.2% of adeno-squamous cell carcinoma, and 15.4% of NSCLC undefined type. In total, 35.6% were positive for presence of EGFR mutations. EGFR mutations were observed 2.2% in exon 18, 61.2% in exon 19, 34.8% in exon 21, and 1.7% in exons 20 and 21. EGFR mutations by histology were 38.2% in adenocarcinoma and 25% in other histologic types (p<0.05). EGFR mutations by demographic were 55.1% in female and 30.3% in male (p<0.05) and 44.8% in non-smoker and 30.3% in smoker (p<0.05). Conclusion: The mutation rate of EGFR in NSCLC in our hospital was 35.6%. The EGFR mutation rates were higher in adenocarcinoma vs other histologic types, in female vs male, and in non-smoker vs smoker. Their differences were statistically significant.

Keywords: EGFR mutations, non-small cell lung cancer.